通用名称为ZOLPIMIST
酒石酸唑吡坦5毫克每计量驱动（一喷）在100microliter;口服液喷雾;樱桃味。

法律分类：
CIV

药理班级ZOLPIMIST
Imidazopyridine催眠。

制造商ZOLPIMIST
ECR制药
适应症ZOLPIMIST
短期治疗失眠与睡眠特征开始困难。

成人剂量为ZOLPIMIST
个性化。每日一次，立即给在睡前。 10毫克（两个actuations）。最大10mg/day。老年，衰弱或肝脏受损：5毫克（一个驱动）;密切监察。伴随中枢神经抑制剂：使用向下调整剂量。延迟的影响，如果与或饭后立即使用。

儿童剂量为ZOLPIMIST
不推荐。

警告/注意事项为ZOLPIMIST
评估共病的诊断（例如，物理和/或精神障碍）治疗前。重新评估后，如果失眠持续7-10天的使用。监控新发生行为变化的抑郁症恶化，或自杀想法。肝损伤。条件是影响代谢或血液动力学反应。损害呼吸功能。睡眠呼吸暂停。重症肌无力。药物滥用者。写出最小的实际金额℞。逐步退出。虚弱。老人。妊娠（Cat.C）。护理母亲。

相互作用的ZOLPIMIST
同时合并其他中枢神经系统抑制剂（如丙咪嗪，氯丙嗪），或酒精添加剂效果（避免）;降低剂量。 Potentiated通过强有力的CYP3A4抑制剂（如酮康唑）;降低剂量唑吡坦。拮抗CYP3A4诱导剂（如利福平）。

为ZOLPIMIST不良反应
嗜睡，头晕，腹泻，迷药的感觉，头痛，思维异常，行为改变（例如，睡眠驾驶）复杂的行为，幻觉，健忘，焦虑等神经精神症状，过敏反应，血管性水肿。

如何ZOLPIMIST提供？
泵（60计量actuations）-1

安眠药酒石酸唑吡坦口腔喷雾剂在美国上市

NovaDel制药公司于 2月4日宣布，采用其给药技术的酒石酸唑吡坦（zolpidem tartrate）口腔喷雾剂Zolpimist已在美国正式推出，使用时可通过灵活计量装置控制5 或10 mg剂量。像大多数催眠药一样，Zolpimist需凭处方配发。

Zolpimist获准于2008年12月22日。在健康成人志愿者中进行的Zolpimist与含同样活性成分的口服片剂Ambien临床对比试验中显示生物等效性。Zolpimist使用方便，唑吡坦能被口腔粘膜迅速吸收，给患者提供了良好选择。Zolpimist由美国Hi-Tech制药公司旗下ECR药品公司生产。

ZOLPIMIST

Generic Name for ZOLPIMIST

Zolpidem tartrate 5mg per metered actuation (one spray) in 100microliter; oral solution spray; cherry-flavor.

Legal Classification:

CIV

Pharmacological Class for ZOLPIMIST

Imidazopyridine hypnotic.

Manufacturer of ZOLPIMIST

ECR Pharmaceuticals

Indications for ZOLPIMIST

Short-term treatment of insomnia characterized by difficulties with sleep initiation.

Adult dose for ZOLPIMIST

Individualize. Give once daily immediately before bedtime. 10mg (two actuations). Max 10mg/day. Elderly, debilitated, or hepatic impaired: 5mg (one actuation); monitor closely. Concomitant CNS depressants: use downward dose adjustments. Effects delayed if used with or immediately after a meal.

Children's dosing for ZOLPIMIST

Not recommended.

Warnings/Precautions for ZOLPIMIST

Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia persists after 7–10 days of use. Monitor for new onset behavioral changes, worsening of depression, or suicidal thinking. Hepatic impairment. Conditions that affect metabolism or hemodynamic response. Compromised respiratory function. Sleep apnea. Myasthenia gravis. Drug abusers. Write ℞ for smallest practical amount. Withdraw gradually. Debilitated. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions for ZOLPIMIST

Additive effects with concomitant other CNS depressants (eg, imipramine, chlorpromazine), or alcohol (avoid); reduce dose. Potentiated by potent CYP3A4 inhibitors (eg, ketoconazole); reduce zolpidem dose. Antagonized by CYP3A4 inducers (eg, rifampin).

Adverse Reactions for ZOLPIMIST

Drowsiness, dizziness, diarrhea, drugged feeling, headache; abnormal thinking, behavioral changes, complex behaviors (eg, sleep-driving), hallucinations, amnesia, anxiety, other neuropsychiatric symptoms; anaphylaxis, angioedema.

How is ZOLPIMIST supplied?

Pump (60 metered actuations)—1