英文药名: Inhibace plus (cilazapril/hydrochlorothiazide Tablets)

中文药名: 一平苏（西拉普利/氢氯噻嗪片）

生产品牌药厂家: Roche Pharmaceuticals

药品名称

一平苏 （原名 ：抑平舒) 片剂 Inhibace
药理作用

口服后被迅速转化成西拉普利拉，为特异性的血管紧张素转换酶抑制剂(ACEI)，它能抑制肾素－血管紧张素－醛固酮系统，从而有效地降低收缩压和舒张压。本药对各种程度的原发性高血压，以及肾性高血压均有效，可单独使用，亦可与其它降压药如非保钾利尿药，β-阻断剂或钙离子拮抗剂联合使用。长期治疗后，突然停用不会引起血压迅速上升。
药代动力学

口服后吸收完全，并迅速转换为活性的西拉普利拉，饭后服用会稍微延迟且降低吸收约15%，但不影响疗效。生物利用度为60%，最高血浆浓度与剂量直接相关，在给药后2小时内达到。西拉普利拉以原型由肾脏排出，每天口服一次的半衰期为9小时。肾功能损害的病人，其血浆浓度比肾功能正常者为高。肾功能正常的老年病人的血浆浓度比年轻人高40%，而清除率亦随着较低的肌酐清除率而降低，中至重度的肝硬变病人药代动力学变化亦相似。
适应症

原发性和肾性高血压。也可与洋地黄和(或)利尿剂合用作为慢性心力衰竭之辅助治疗。
用法用量

原发性高血压
2.5-5 mg，每日1次，先从小量开始，根据血压的反应调整剂量。每2-4周调整1次。
肾性高血压
剂量应由500 ug或更低开始，维持剂量应个体化。
正在服用利尿药的高血压病人
服用本药前2-3天，应停止服用利尿药。若病人情况不允许，剂量应由500 ug，每日1次开始，维持剂量个体化。
肾衰竭
作血液透析的病人应在非透析日服用，其剂量应根据血压反应而进行调整。
根据肌酐清除率使用剂量如下：肌酐清除率>40 mL/分，10-40 mL/分，起始剂量分别为1 mg/次/日和500 ug/次/日；最大剂量分别为5 mg/次/日和2.5 mg/次/日。肌酐清除率<10 mL/分时，剂量为250-500 ug，每周1-2次。
老年病人
以每日500 ug为起始剂量进行治疗。并根据不同病人的耐受性、疗效及临床状况以1-2.5 mg 的剂量用药。
任何疑问，请遵医嘱！
不良反应

头痛、眩晕，偶可发生疲倦、低血压，消化不良、恶心，丘疹，咳嗽，血管神经性水肿。偶有血清肌酐及尿素升高。 禁忌症 腹水患者，妊娠及哺乳妇女，儿童，对其它ACEI制剂过敏者。
注意事项

肝硬化，严重肾功能损害，低钠和血容量不足者，充血性心衰病人慎用。
儿童用药

儿童慎用。
药物相互作用

与其它降压药并用，可有相加作用，与保钾利尿药合用可导致血钾增加，特别是肾损害的病人。与非甾体抗炎药合用，可降低本药的降压作用。与有抗压作用的麻醉药联合使用可产生低血压。
药物过量 可能发生低血压症状，应予扩容治疗。必要时，可藉血液透析将活性型西拉普利拉自体内排除。

Teva-Cilazapril
Common Name
cilazapril

In this drug factsheet:
How does Teva-Cilazapril work?
What will it do for me?

How should I use Teva-Cilazapril?

What form(s) does Teva-Cilazapril come in?

Who should NOT take Teva-Cilazapril?

What side effects are possible with Teva-Cilazapril?

Are there any other precautions or warnings for Teva-Cilazapril?

What other drugs could interact with Teva-Cilazapril?

DIN (Drug Identification Number)

02266350  TEVA-CILAZAPRIL 1MG TABLET
02266369  TEVA-CILAZAPRIL 2.5MG TABLET
02266377  TEVA-CILAZAPRIL 5MG TABLET

How does this medication work? What will it do for me?

Cilazapril belongs to the family of medications known as ACE inhibitors. It is used to treat high blood pressure and congestive heart failure. Cilazapril controls blood pressure and reduces symptoms of congestive heart failure by relaxing blood vessels and by making the heart pump more efficiently.

For treatment of high blood pressure, cilazapril may be used alone or in combination with diuretics (water pills) known as thiazide diuretics (e.g., hydrochlorothiazide) when one medication has not been found to control blood pressure satisfactorily.

For treatment of congestive heart failure, cilazapril is used in addition to digoxin or thiazide diuretics or both.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The usual recommended doses range from 2.5 mg to 10 mg once daily, depending on the condition being treated as well as the person's kidney and liver function. The initial starting dose may be as low as 0.5 mg once daily. Cilazapril should be taken at the same time each day, with or without food.

The dose range for treatment of high blood pressure is 2.5 mg to 10 mg once daily.

The dose range for congestive heart failure is 2.5 mg to 5 mg once daily taken.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?

1 mg
Each yellow, oval-shaped, biconvex, film-coated tablet, engraved with "N|N" on one side and "1" on the other side, contains anhydrous cilazapril 1 mg as cilazapril monohydrate. Nonmedicinal ingredients: cornstarch, hypromellose, iron oxide yellow, lactose, macrogol, microcrystalline cellulose, polysorbate, sodium stearyl fumarate, talc, and titanium dioxide.

2.5 mg
Each pinkish-brown, oval-shaped, biconvex, film-coated tablet, engraved with "N|N" on one side and "2.5" on the other side, contains anhydrous cilazapril 2.5 mg as cilazapril monohydrate. Nonmedicinal ingredients: cornstarch, hypromellose, iron oxide red, lactose, macrogol, microcrystalline cellulose, sodium stearyl fumarate, talc, and titanium dioxide.

5 mg
Each reddish-brown, oval-shaped, biconvex, film-coated tablet, engraved with "N|N" on one side and "5" on the other side, contains anhydrous cilazapril 5 mg as cilazapril monohydrate. Nonmedicinal ingredients: cornstarch, glycerol, hypromellose, iron oxide red and yellow, lactose, macrogol, microcrystalline cellulose, polydextrose, sodium stearyl fumarate, talc, titanium dioxide, and triacetate.

Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

Who should NOT take this medication?

Cilazapril should not be taken by anyone who:

is allergic to cilazapril or to any ingredients of this medication
is pregnant
has a history of angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any ACE inhibitors
has ascites (swollen abdomen due to liver problems)

Teva-Cilazapril(cilazapril)

How does this medication work? What will it do for me?
Cilazapril belongs to the family of medications known as ACE inhibitors. It is used to treat high blood pressure and congestive heart failure. Cilazapril controls blood pressure and reduces symptoms of congestive heart failure by relaxing blood vessels and by making the heart pump more efficiently.

For treatment of high blood pressure, cilazapril may be used alone or in combination with diuretics (water pills) known as thiazide diuretics (e.g., hydrochlorothiazide) when one medication has not been found to control blood pressure satisfactorily.

For treatment of congestive heart failure, cilazapril is used in addition to digoxin or thiazide diuretics or both.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?
1 mg
Each yellow, oval-shaped, biconvex, film-coated tablet, engraved with "N|N" on one side and "1" on the other side, contains anhydrous cilazapril 1 mg as cilazapril monohydrate. Nonmedicinal ingredients: cornstarch, hypromellose, iron oxide yellow, lactose, macrogol, microcrystalline cellulose, polysorbate, sodium stearyl fumarate, talc, and titanium dioxide.

2.5 mg
Each pinkish-brown, oval-shaped, biconvex, film-coated tablet, engraved with "N|N" on one side and "2.5" on the other side, contains anhydrous cilazapril 2.5 mg as cilazapril monohydrate. Nonmedicinal ingredients: cornstarch, hypromellose, iron oxide red, lactose, macrogol, microcrystalline cellulose, sodium stearyl fumarate, talc, and titanium dioxide.

5 mg
Each reddish-brown, oval-shaped, biconvex, film-coated tablet, engraved with "N|N" on one side and "5" on the other side, contains anhydrous cilazapril 5 mg as cilazapril monohydrate. Nonmedicinal ingredients: cornstarch, glycerol, hypromellose, iron oxide red and yellow, lactose, macrogol, microcrystalline cellulose, polydextrose, sodium stearyl fumarate, talc, titanium dioxide, and triacetate.

Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

How should I use this medication?
The usual recommended doses range from 2.5 mg to 10 mg once daily, depending on the condition being treated as well as the person's kidney and liver function. The initial starting dose may be as low as 0.5 mg once daily. Cilazapril should be taken at the same time each day, with or without food.

The dose range for treatment of high blood pressure is 2.5 mg to 10 mg once daily.

The dose range for congestive heart failure is 2.5 mg to 5 mg once daily taken.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?
Cilazapril should not be taken by anyone who:

is allergic to cilazapril or to any ingredients of this medication
is pregnant
has a history of angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any ACE inhibitors
has ascites (swollen abdomen due to liver problems)
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

cough (dry, persistent)
diarrhea
headache
loss of taste
nausea
unusual tiredness
weakness (loss of energy)
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

abdominal pain
abdominal distention
blood in the stool
shortness of breath or difficulty breathing
chest pain
confusion
difficulty urinating
dizziness, lightheadedness, or fainting (signs of low blood pressure)
fever and chills
hoarseness
irregular heartbeat
itching of skin
 nausea or vomiting
nervousness
numbness or tingling in hands, feet, or lips
pain when urinating
ringing in the ear(s)
skin rash (with or without itching, fever, or joint pain)
stomach pain
symptoms of the flu (e.g., sinus pain, runny nose, sore throat, cough)
vision problems
weakness or heaviness of legs
yellowing of eyes or skin
 

Stop taking the medication and seek immediate medical attention if any of the following occur:

difficulty swallowing or breathing (sudden)
swelling of face, mouth, hands, or feet (signs of angioedema)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Angioedema: Angioedema is a serious allergic reaction that causes the area around the face, throat, and tongue to swell. It may occur with use of cilazapril. If you experience swelling of the face, tongue, or throat, stop taking cilazapril at once and get immediate medical attention. Other ACE inhibitors should not be taken in the future. People who have had angioedema caused by other substances may be at increased risk of angioedema while receiving cilazapril.

Cough: ACE inhibitors such as this medication may cause you to develop a dry, persistent cough within hours of the first dose to weeks or months after starting therapy. The cough usually resolves within 4 weeks of stopping this medication. Talk to your doctor if you develop a persistent, intolerable cough.

Fluid and electrolyte balance: Increases in blood levels of potassium occur for some people who take this medication. This rarely causes problems, but potassium levels should be monitored by your doctor. People with kidney disease or diabetes are at a higher risk of having increased blood potassium while taking cilazapril. These people should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Infection: Report any signs of infection such as sore throat or fever to your doctor.

Kidney function: Changes in kidney function have been noticed in certain people (e.g., people with narrowed blood vessels in their kidneys, or those with severe congestive heart failure). The use of diuretics (water pills) may further increase risk of kidney problems in those at risk for this problem. Let your doctor know if you notice any decreases in urine output or increases in the swelling of lower limbs, suggesting accumulation of fluid due to decreased urination.

Liver disease: This medication may worsen liver disease. People with liver disease or decreased liver function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Low blood pressure: Occasionally, blood pressure drops too low after taking cilazapril. This usually happens after the first or second dose, or when the dose is increased. It is more likely to occur for people who take water pills, have a salt-restricted diet, are on dialysis, are suffering from diarrhea or vomiting, or have been sweating excessively and not drinking enough liquids. If low blood pressure causes you to faint or feel lightheaded, contact your doctor.

Pregnancy: This medication should not be taken by pregnant women. If you become pregnant, stop taking cilazapril at once and contact your doctor.

Breast-feeding: This medication passes into breast milk. This medication should not be taken by breast-feeding women. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of cilazapril have not been established for children. Its use by this age group is not recommended.

What other drugs could interact with this medication?
There may be an interaction between cilazapril and any of the following:

allopurinol
cyclosporine
diuretics (e.g., hydrochlorothiazide, furosemide)
insulin
medications that lower blood pressure (e.g., beta-blockers such as propranolol or metoprolol)
medications that increase potassium levels (e.g., potassium supplements, spironolactone, amiloride, triamterene, and salt substitutes containing potassium)
nonsteroidal anti-inflammatory medications (NSAIDs; e.g., ibuprofen, indomethacin, naproxen)
oral antidiabetes medication
rituximab
tetracyclines (e.g., tetracycline, minocycline, doxycycline)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

【中文品名】西拉普利
【药效类别】抗高血压药>卡托普利类
【通用药名】CILAZAPRIL
【别　　名】Cilazil, Dynorm, Inhibace, Inibace, Initiss, Justor, Prilazid, Ro-31-2201, Ro-31-2848, Ro-31-3113, Vascace, Vascase
【化学名称】 6H-Pyridazino[1,2-a][1.2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R)]]-
【CA登记号】[88768-40-5], [90139-06-3]
【结 构 式】

【分 子 式】CHNOPS·
【分 子 量】
【收录药典】
【开发单位】罗氏
【首次上市】1990年，日本