英文药名: Rythmol SR(Propafenone Capsules)

中文参考药名: 普罗帕酮胶囊

生产厂家: Not available

药品名称

普罗帕酮 Propafenone
中文别名：普罗帕酮、丙胺苯丙酮、丙苯酮、丙酚酮、利他脉、利它脉、普鲁帕酮、替罗帕酮、心律平、盐酸普罗帕酮、羟丙苯丙酮
英文别名：Baxarytmon、Berarytmon、Bexarytmon、Fenopraine、Rythmol、Rytmonorma
药品类别：抗心律失常药
规格

盐酸普罗帕酮片150mg , 225mg, 300mg
药理药动

药效学
本品属Ic类抗心律失常药。其电生理效应是抑制快钠离子内流，减慢收缩除极速度，使传导速度减低，轻度延长动作电位间期及有效不应期，主要作用在心房及心肌传导纤维，故对房性心律失常可能有效。对房室旁路的前向及逆向传导速度也有延长作用。可提高心肌细胞阈电位。故本品具有减低传导速度，延长有效不应期及降低兴奋性消除折返性心律失常的作用。此外本品也有轻度β受体阻滞作用及慢钙离子通道阻滞作用，轻至中度抑制心肌收缩力，后者的程度与剂量有关。
药动学
口服吸收良好，首次关卡效应明显。生物利用度因剂量及剂型而异，约4.8～23.5％。剂量增加2倍, 血药浓度可增加5 倍, 呈饱和动力学特点。吸收后主要分布肺组织，其浓度比心肌及肝脏组织内浓度高10倍，比骨骼肌及肾脏高20倍。 稳态表观分布容积为1.9～3.0L/kg。蛋白结合率约为97％。单次服药半衰期约3～4小时，多次服药约6～7小时, 口服后0.5～1小时作用开始, 2～3小时达最大作用, 作用可持续6～8小时(4～22小时)。口服2～3小时血药浓度达峰值, 有效血药浓度个体差异大, 平均约588～800ng/ml(64～3271ng/ml), 且血药浓度与剂量不成比例增加, 故用药需个体化。 中毒血药浓度约1000ng/ml。主要经肝脏代谢，其代谢产物5-羟基-丙胺基苯丙酮具有药理活性。约1％以原药经肾排出, 90%以氧化代谢物经肠道及肾脏清除。
适 应 症

口服适用于室性早搏及阵发性室性心动过速。其次为室上性心律失常，包括房性早搏、阵发性室上性心动过速及预激综合征伴室上性心动过速、心房扑动或心房颤动,但纠正心房颤动或心房扑动效果差。
静注适用于阵发性室性心动过速及室上性心动过速( 包括伴预激综合征者)。
用法用量

1．口服成人常用量：一次100—200mg，6～8小时一次。
成人处方极量：一日900mg，分次服。
小儿常用量：一次按体重5—7mg／kg，一日 3次，起效后用量减半，维持疗效。
2．静脉注射
成人常用量：一次按体重 1～1.5mg／kg，静注5分钟，必要时20分钟后可重复一次。以后可以每分钟0.5—1mg速度滴入维持。
小儿常用量：一次按体重1mg／kg，静注5分钟，必要时20分钟后可重复一次。
任何疑问，请遵医嘱！
不良反应

不良反应与剂量相关。
(1)心血管：可产生心动过缓心脏停搏及传导阻滞，尤其原有窦房结或房室结功能障碍者，应停药并静脉用阿托品或异丙肾上腺素。必要时起搏治疗。有促心律失常作用。4.4％产生低血压，尤其在原有心功能不全者，可用升压药、异丙肾上腺素等，也可加重或诱发心力衰竭，故对原有心力衰竭者应合用强心及利尿药。
(2)胃肠：食欲减退、恶心、呕吐及便秘，也可产生口干及舌唇麻木。减药或停药可消失。
(3)神经：头晕、目眩。减药或停药可消失。
(4)其他：肝脏转氨酶升高，停药后 2—4周恢复正常。
禁忌症

(1)老年人用药后可能引起血压下降，应注意观察。
(2)以下情况应禁用：
①窦房结功能障碍；
②Ⅱ或Ⅲ度房室传导阻滞，双束支传导阻滞(除非已有起博器)；
③心源性休克。
(3)以下情况应慎用：
①严重窦性心动过缓；
②Ⅰ度房室传导阻滞；
③低血压；
④肝或肾功能障碍。
药物相互作用

(1)其他抗心律失常药，包括维拉帕米、普萘洛尔、胺碘酮及奎尼丁等，可能增加本品不良反应。
(2)降压药可使本品的降压作用增强。

Rythmol Description
This medicine is a Class 1C anti-arrhythmic medicine used to treat an irregular heartbeat and to help maintain a normal heart rhythm in patients without structural heart disease.

Rythmol Directions
Follow the directions for using this medicine provided by your doctor. TAKE THIS MEDICINE with food or milk. Take each dose at the same time with respect to meals. STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light. IF YOU MISS A DOSE OF THIS MEDICINE, take it if you remember within 4 hours of the missed dose. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Rythmol Cautions
DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. DO NOT EXCEED THE RECOMMENDED DOSE. DO NOT SUDDENLY STOP TAKING THIS MEDICINE without checking with your doctor. Some conditions may become worse when the medicine is suddenly stopped. Laboratory and/or medical tests, including EKGs, may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. THIS MEDICINE MAY CAUSE dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. EATING GRAPEFRUIT OR DRINKING GRAPEFRUIT JUICE while you are taking this medicine may increase the amount of this medicine in your blood, which may increase your risk for serious side effects. Talk with your doctor before including grapefruit or grapefruit juice in your diet. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine.

Rythmol Side Effects
SIDE EFFECTS that may occur while taking this medicine include dizziness or lightheadedness, drowsiness, constipation, gas, tiredness, or change in taste. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain, unusual bruising or bleeding, irregular heartbeat, fast or slow heartbeat, shortness of breath, swelling of the hands or the feet, fever, sore throat, chills, unexplained weakness, muscle weakness, tremor, blurred vision, prolonged diarrhea, sweating, vomiting, or loss of appetite or thirst. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Rythmol Active Ingredients
Propafenone