Generic Name for LEXIVA
Fosamprenavir (as calcium) 700mg; tabs; (prodrug of amprenavir).
Legal Classification:
Rx
Pharmacological Class for LEXIVA
HIV-1 protease inhibitor.
Manufacturer of LEXIVA
GlaxoSmithKline Pharmaceuticals
Indications for LEXIVA
HIV-1 infection.
Adult dose for LEXIVA
Oral susp: take without food; if emesis occurs within 30 minutes after dosing, re-dose. Therapy-naive: 1.4g twice daily; or fosamprenavir 1.4g + ritonavir 200mg once daily; or fosamprenavir 1.4g + ritonavir 100mg once daily; or fosamprenavir 700mg + ritonavir 100mg twice daily. Protease-inhibitor-experienced: fosamprenavir 700mg + ritonavir 100mg twice daily. Hepatic dysfunction: see literature for dose adjustments.
Children's dosing for LEXIVA
<2yrs: not recommended. Oral susp: take with food; if emesis occurs within 30 minutes after dosing, re-dose. Therapy-naive: 2–5yrs: 30mg/kg twice daily. ≥6yrs: fosamprenavir 30mg/kg twice daily; or fosamprenavir 18mg/kg + ritonavir 3mg/kg twice daily. Therapy-experienced: ≥6yrs: fosamprenavir 18mg/kg + ritonavir 3mg/kg twice daily. For all: do not exceed the adult dosage (see literature). Alternative oral tabs regimen: see literature.
Also:
LEXIVA ORAL SUSPENSION
Contraindications for LEXIVA
Concomitant cisapride, pimozide, ergots, midazolam, triazolam, possibly others; see literature. Concomitant flecainide, propafenone, or oral contraceptives with ritonavir-boosted fosamprenavir. St. John's wort, rifampin, lovastatin, simvastatin, delavirdine: not recommended.
Warnings/Precautions for LEXIVA
Sulfonamide allergy. Hepatic impairment: see literature. Do not exceed recommended dose. Discontinue if severe rash occurs. Monitor lipids, liver function, and for fat redistribution and hyperglycemia. Hemophilia: monitor for spontaneous bleeding. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for LEXIVA
See Contraindications. Life-threatening arrhythmias possible with bepridil. Concomitant nevirapine without ritonavir: not recommended. Reduce rifabutin dose by at least ½ (or by 75% if with ritonavir) and monitor for neutropenia (do weekly CBCs). Potentiates sildenafil, tadalafil, vardenafil; reduce doses of these. May potentiate fluticasone (consider alternative therapy), trazodone (reduce trazodone dose). Monitor amiodarone, anticonvulsants (eg, phenytoin), H2 blockers, immunosuppressants, lidocaine (systemic), quinidine, tricyclics, warfarin, drugs that affect or are affected by CYP3A4 (eg, azole antifungals, benzodiazepines, calcium channel blockers, macrolides, NNRTIs, protease inhibitors, statins, steroids). May antagonize, or be antagonized by antacids, hormonal contraceptives (use non-hormonal methods), methadone.
Adverse Reactions for LEXIVA
GI upset, headache, rash (may be serious, eg, Stevens-Johnson), fat redistribution, depression, fatigue, hypertriglyceridemia, elevated liver enzymes, immune reconstitution syndrome, vomiting (esp. children).
Notes for LEXIVA
Register pregnant patients exposed to fosamprenavir by calling (800) 258-4263.
How is LEXIVA supplied?
Tabs—60; Susp—225mL
通用名称为LEXIVA
Fosamprenavir（钙）700mg;标签;（安普那韦的前体药物）。
法律分类：
接收
类药物为LEXIVA
HIV - 1蛋白酶抑制剂。
制造商的LEXIVA
葛兰素史克制药
主治为LEXIVA
HIV - 1感染。
成人剂量为LEXIVA
口腔SUSP：没有食物，如果呕吐发生在服药后30分钟内，重新剂量。治疗天真：1.4克每日两次;或fosamprenavir1.4克+利托那韦为200mg，每日一次;或fosamprenavir1.4克+利托那韦100毫克，每天一次;或fosamprenavir 700mg +利托那韦100毫克，每日两次。经验丰富的蛋白酶抑制剂：fosamprenavir 700mg +利托那韦100毫克，每天两次。肝功能不全：调整剂量的文献。
儿童剂量为LEXIVA
<2yrs：不推荐。口服悬液：采取与食品;如果呕吐发生在服药后30分钟内，重新剂量。治疗天真：2 5yrs：30mg/kg，每日两次。 ≥6yrs：fosamprenavir 30mg/kg，每日两次;或fosamprenavir 18mg/kg +利托3mg/kg，每日两次。经验丰富的治疗：≥6yrs：fosamprenavir 18mg/kg +利托3mg/kg，每日两次。对于所有不超过成人剂量（见文献）。替代疗法口服标签：见文献。
另外：
LEXIVA口头悬挂
禁忌症为LEXIVA
同时服用西沙必利，匹莫齐特，ergots，咪达唑仑，三唑仑，可能还有其他看到的文献。伴随氟卡尼，普罗帕酮，或与利托那韦，推动fosamprenavir口服避孕药。圣约翰草，利福平，洛伐他汀，辛伐他汀，地拉韦啶：不推荐。
为LEXIVA警告/注意事项
磺胺类药物过敏。肝功能损害：见文献。不要超过推荐剂量。停止，如果发生严重的皮疹。监视器血脂，肝功能，脂肪的再分配和高血糖。血友病：自发性出血监测。老人。怀孕（Cat.C）。哺乳的母亲：不推荐。
为LEXIVA的相互作用
见禁忌。苄普地尔可能危及生命的心律失常。伴随无利托那韦，奈韦拉平：不建议。利福布丁剂量减少至少1.5（或75％如果与ritonavir）和中性粒细胞减少显示器（做每周CBCS）。 Potentiates西地那非，他达拉非，伐地那非;减少这些剂量。五月与力量氟替卡松（考虑替代疗法），曲唑酮（降低曲唑酮剂量）。监视器胺碘酮，抗惊厥药（如苯妥英），H2受体阻滞剂，免疫抑制剂，利多卡因（全身），奎尼丁，三环，华法林，药物影响或影响通过CYP3A4（例如，唑类抗真菌药，苯二氮卓类药物，钙通道阻滞剂，大环内酯类，NNRTIs，蛋白酶抑制剂，他汀类药物，类固醇）。五月对抗，或抗酸剂，激素避孕药（使用非激素的方法），美沙酮拮抗作用。
LEXIVA的不良反应
胃肠不适，头痛，皮疹（可能是严重的，例如，史蒂文斯 - 约翰逊），脂肪的再分配，抑郁，疲劳，高甘油三酯血症，肝酶升高，免疫重建综合征，呕吐（尤其是儿童）。
为LEXIVA的注意事项
注册暴露怀孕的患者通过拨打（800）258-4263 fosamprenavir。
如何LEXIVA提供？
标签60; SUSP - 225mL