部份中文羟苯磺酯钙处方资料（仅供参考） 药品英文名 Dobesilate Calcium 药品别名 羟苯磺酯钙、多贝斯、二羟苯磺酯钙、氢醌磺酯钙、CalciumDobesilate、Doxium  药理作用 本品为新型血管保护剂。可降低血浆黏度，阻碍血小板聚集，防止血栓形成，降低毛细血管的通透性，增强血管壁的韧性。纠正血浆中白蛋白与球蛋白的比值，改善淋巴回流，减少和消除水肿。此外，本品还可抑制多种血管活性物质(如组胺、5-HT、缓激肽、玻璃酸酶、前列腺素)对周围血管所致的高通透性作用，减少血管内壁损伤，改善基底膜胶原的合成。 药动学 本品口服后易于吸收，3h可达血药峰值，并维持10h左右。消除t1/2约为5h。蛋白结合率为20%～25%。主要以原药随尿和粪便排出，24h内随尿排出的代谢物约占10%。 适应证 预防和治疗周围循环障碍引起的疾病，如： 1.糖尿病性视网膜病。 2.防治心绞痛、心肌梗死、脑血栓形成和栓塞后遗症以及肾小球动脉硬化。 3.纠正高血黏度引起的循环障碍，防止血栓形成，减轻因循环不畅所引起的多种淤滞症状，如四肢麻木、手脚厥冷、下肢沉重、头晕、头痛以及皮肤瘙痒等。 4.静脉曲张综合征。 禁忌证 1.对本品过敏者、儿童禁用。 2.由于孕妇和哺乳者的用药安全性尚未确定，暂不使用。 3.活动性消化性溃疡者慎用或禁用。 注意事项 有血小板减少史或出血史者慎用。 不良反应 偶有胃部不适、烧灼感、恶心和厌食，停药后可见消失。 用法用量 1.本品为胶囊，进餐时口服，但不可嚼碎。 2.糖尿病性视网膜病变：口服1粒，每天3次，疗程3～5个月。见效后，改为每天2粒，直至疗效明显。 3.用于周围循环障碍所引起的疾病：口服1粒，每天3次，疗程1～2个月，见效后，改为每天2粒，直至症状消失。 4.下肢静脉曲张综合征：口服1粒，每天2次，疗程1～3周。一般用药5～6天后即可见效，继服每天1粒，以巩固疗效。 药物相应作用 不宜与其他抗凝药、抗血小板药合用，以免产生不良的相互作用。 专家点评 本品为新型血管保护剂。可降低血浆黏度、阻碍血小板聚集、防止血栓形成。此外，本品还可抑制多种血管活性物质(如组胺、5-HT、缓激肽、前列腺素)对周围血管所致的高通透性作用，减少血管内壁损伤、改善基底膜胶原的合成。适用于预防和治疗周围循环障碍引起的疾病。 DOXIUM® tablets SCHEDULING STATUS: Schedule 2 PROPRIETARY NAME (and dosage form): DOXIUM® tablets COMPOSITION: One tablet contains 250 mg of the active substance calcium dobesilate. PHARMACOLOGICAL CLASSIFICATION: A. 8.1 Coagulants, haemostatics. PHARMACOLOGICAL ACTION: DOXIUM tablets act selectively on the capillary walls regulating their physiological functions of resistance and permeability. This action is beneficial in all cases of capillary fragility due to metabolic disturbances (constitutional or acquired), to surgical stress or induced by certain medicines. INDICATIONS: DOXIUM tablets are recommended as the vascular treatment of choice indiabetic retinopathy. It has been used with good effect as a haemostatic during surgical procedures in otorhinolaryngology, ophthalmology and dentistry. CONTRA-INDICATIONS: There are no known contra-indications but on general principles DOXIUM tablets should not be administered during the first trimester of pregnancy. DOSAGE AND DIRECTIONS FOR USE: The usual daily dose is 2 to 3 tablets of 250 mg swallowed whole at meals. Duration of treatment may be from one week to several months or longer depending upon the disease condition. Half the above dose is recommended for infants. SIDE-EFFECTS AND SPECIAL PRECAUTIONS: Rarely in sensitive persons some nausea or gastric discomfort may occur but this rapidly disappears if the dose is decreased. KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: This has not been encountered. In view of the extremely low toxicity of the medicines no symptoms can be predicted but if poisoning or overdosage is suspected it is recommended on general principles that vomiting be induced or gastric lavage be performed, and such symptomatic supportive therapy be administered as appears indicated. CONDITIONS OF REGISTRATION: None. IDENTIFICATION: A white, smooth biconvex tablet of 11,0 mm diameter with the mark "d." engraved on one side. PRESENTATION: DOXIUM tablets are supplied in bottles of 100 tablets. Each tablet contains 250 mg calcium dobesilate. STORAGE INSTRUCTIONS: Keep out of reach of children. Store below 30°C.