英文药名: Quinidine Gluconate Tablets

中文药名: 葡萄糖酸奎尼丁片

药品说明

适应症
主要用于治疗心房颤动和心房扑动，可使房颤或房扑停止，是几乎唯一能使房颤或房扑恢复窦性心律的药物。由于奎尼丁具有抗胆碱作用，在治疗房颤或房扑时，在减慢心房率的同时，有时可使心室率进一步加快，故对房颤、房扑患者应先用强心甙控制心室率后再用本品，以停止房颤或房扑；亦可用于治疗房性早搏、室性早搏、阵发性心动过速。

用法用量
口服：每次１～２片，每８～１２小时１次。
肌注或静注：每次０．４ｇ，用５％葡萄糖溶液稀释后缓注，并用心电图观察，定时记录动脉压。每日０．３～２．４ｇ。

注意事项
本品毒副反应较大，安全范围小。可有恶心、呕吐、腹泻、头痛、耳鸣、视力模糊、精神紊乱、心动过速、心动过缓、变态反应（如皮疹、呼吸困难、发绀、药疹、喉头水肿，甚至休克、心室停搏；偶有血小板和白细胞减少、肝功能损害等变态反应）、血栓脱落、低血压、奎尼丁晕厥及诱发心力衰竭，故宜先服小量，观察反应后再继续用药；在心电图监护下应用，如心电图ＱＲＳ波增宽３０％时，应立即停药。严重心力衰竭、传导阻滞、心动过缓、窦房结功能低下、严重心肌损害、低血压、孕妇、严重肝肾功能不全、有过敏反应者、洋地黄中毒、青光眼患者忌用，房颤超过半年的患者一般不用。

规格
长效缓释片：０．３３ｇ（相当于奎尼丁０．２ｇ）。

包装规格：324mg*100 片

Quinidine Gluconate Controlled-Release TabletsGeneric Name: Quinidine Gluconate (KWIN-ih-deen)Brand Name: Generic only. No brands available.
Quinidine Gluconate Controlled-Release Tablets are associated with an increased risk of death when used to treat non-life-threatening irregular heartbeat. This risk may be greater if you have structural heart disease. Talk with your doctor for more information.

Quinidine Gluconate Controlled-Release Tablets are used for:
Treating and preventing abnormal heart rhythms.

Quinidine Gluconate Controlled-Release Tablets are an antiarrhythmic. It works by stabilizing the heart rhythm in conditions in which the heart is beating too fast or in an irregular rhythm (antiarrhythmic effect).

Do NOT use Quinidine Gluconate Controlled-Release Tablets if:
you are allergic to any ingredient in Quinidine Gluconate Controlled-Release Tablets
you have certain severe, uncontrolled abnormal heart rhythms or muscle weakness due to myasthenia gravis, or you have previously developed unusual bruising while using Quinidine Gluconate Controlled-Release Tablets or similar medications
you are currently taking astemizole, codeine, cisapride, a class III antiarrhythmic (eg, amiodarone), grepafloxacin, an H1 antagonist (eg, diphenhydramine), itraconazole, a ketolide (eg, telithromycin), a macrolide (eg, erythromycin), a nondepolarizing muscle relaxant (eg, pancuronium), a phenothiazine (eg, chlorpromazine), a phosphodiesterase type 5 inhibitor (eg, sildenafil), pimozide, a quinolone (eg, ciprofloxacin), ritonavir, sparfloxacin, succinylcholine, terfenadine, voriconazole, or medicine for myasthenia gravis
Contact your doctor or health care provider right away if any of these apply to you.

Before using Quinidine Gluconate Controlled-Release Tablets:
Some medical conditions may interact with Quinidine Gluconate Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have liver or kidney disease; congestive heart failure, a history of heart block, QT prolongation, or other heart problems; low blood pressure; high or low blood calcium levels; decreased blood platelets; or digitalis intoxication
Some MEDICINES MAY INTERACT with Quinidine Gluconate Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), nifedipine, or rifampin because the effectiveness of Quinidine Gluconate Controlled-Release Tablets may be decreased
Amiloride, amiodarone, carbonic anhydrase inhibitors (eg, acetazolamide), cimetidine, itraconazole, ketoconazole, thiazide diuretics (eg, hydrochlorothiazide), verapamil, or voriconazole because side effects, such as increased risk of low blood pressure or heart conduction disturbances and racing heart rate, dizziness, or fainting, may occur
Arsenic, cisapride, class III antiarrhythmics (eg, amiodarone), dofetilide, droperidol, H1 antagonists (eg, diphenhydramine), haloperidol, HIV protease inhibitors (eg, indinavir), ketolides (eg, telithromycin), macrolides (eg, erythromycin), phenothiazines (eg, chlorpromazine), phosphodiesterase type 5 inhibitors (eg, sildenafil), pimozide, quinolones, streptogramins (eg, pristinamycin), or ziprasidone because the actions and side effects of Quinidine Gluconate Controlled-Release Tablets and these medicines may be increased
Anticoagulants (eg, warfarin), aripiprazole, beta-adrenergic blockers (eg, metoprolol), digitoxin, digoxin, nondepolarizing muscle relaxants (eg, pancuronium), norepinephrine reuptake inhibitors (eg, atomoxetine), procainamide, propafenone, or succinylcholine because the actions or side effects of these medicines may be increased
Anticholinesterases (eg, pyridostigmine) or narcotic analgesics (eg, codeine) because the effectiveness of these medicines may be decreased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Quinidine Gluconate Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Quinidine Gluconate Controlled-Release Tablets:
Use Quinidine Gluconate Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Quinidine Gluconate Controlled-Release Tablets may be taken with or without food. Take Quinidine Gluconate Controlled-Release Tablets with a full glass of water.
Swallow whole. Do not crush or chew before swallowing.
Do not lie down for 30 minutes after taking Quinidine Gluconate Controlled-Release Tablets.
Do not drink grapefruit juice or eat grapefruit while taking Quinidine Gluconate Controlled-Release Tablets.
Use Quinidine Gluconate Controlled-Release Tablets on a regular schedule around the clock, unless otherwise directed by your doctor.
If you miss a dose of Quinidine Gluconate Controlled-Release Tablets, take it as soon as possible. If it is almost time for our next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Quinidine Gluconate Controlled-Release Tablets.

Important safety information:
Quinidine Gluconate Controlled-Release Tablets may cause dizziness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Quinidine Gluconate Controlled-Release Tablets.
Quinidine Gluconate Controlled-Release Tablets may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Quinidine Gluconate Controlled-Release Tablets. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
Do not suddenly stop taking Quinidine Gluconate Controlled-Release Tablets without checking with your doctor.
Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Quinidine Gluconate Controlled-Release Tablets.
LAB TESTS may be performed to check for side effects. Be sure to keep all doctor and lab appointments.
Use Quinidine Gluconate Controlled-Release Tablets with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Quinidine Gluconate Controlled-Release Tablets during pregnancy. Quinidine Gluconate Controlled-Release Tablets are excreted in breast milk. Do not breast-feed while you are taking Quinidine Gluconate Controlled-Release Tablets.
Possible side effects of Quinidine Gluconate Controlled-Release Tablets:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; diarrhea; heartburn; nausea; stomach discomfort; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; deafness; dizziness; fainting; fast or slow heartbeat; headache; hearing loss; irregular heartbeat; lightheadedness; liver toxicity; pale stools; psychotic reactions; ringing in ears; yellowing of the skin or eyes.