英文药名: Lexiva(Fosamprenavir Oral Suspension) 中文药名: 福沙那伟口服液 生产厂家: Glaxo Smith Kline 药品简介 福沙那韦钙是FDA批准用于抗人类免疫缺陷病毒(HIV)感染的新药,是用于控制HIV感染的蛋白酶抑制药类新药,可抑制HIV病毒蛋白酶,降低病毒载量,提高CD+4细胞计数。 2009年12月3日，美国食品药品管理局（FDA）和葛兰素史克公司(GSK)发布了一条有关成人人类免疫缺陷病毒(HIV)感染者应用Lexia(福沙那韦)与心肌梗死(MI)和血脂异常之间存在潜在相关性的通告。Lexiva适宜与其他抗逆转录病毒药物联用治疗HIV感染。 生产厂家对Lexiva处方信息中现有的警告和注意事项栏目进行了修改，指出应用该药治疗可导致胆固醇水平升高情况的发生。此外，还强调了控制血脂的重要性，而且说明书中还建议在开始Lexiva治疗前以及治疗期间进行定期甘油三酯和胆固醇检测。 GSK还在Lexiva片剂和口服悬液处方信息的不良反应中增加了MI和高胆固醇血症。2009年2月的国际HIV大会上公布了法国医院HIV数据库中的一项病例对照研究的数据。该研究由欧洲药品评审局(European Medicines Evaluation Agency)倡导，旨在分析应用特异性核苷酸反转录酶抑制剂及蛋白酶抑制剂对MI风险的影响。研究员报告指出，研究发现，福沙那韦/安普那韦累积用药与MI风险增加有关(风险比值比，1.52/增加1年用药；95%可信区间，1.19~1.95)。 GSK公司在向医护专业人员发布的这项最新通告中表示，MI已被确定为蛋白酶抑制剂类药物的常规信号。GSK宣称，所报告的相关性本身看似有据可循，可能与这类药物促进血脂水平升高的特性有关。生产厂家同时还提醒处方者，HIV感染本身就一直与血脂代谢异常和缺血性心脏病有关联。 包装规格： 50 mg/ml *225ml   Lexiva, developed by GlaxoSmithKline, was first approved by the Food and Drug Administration in 1999 to be used in treating patients with HIV. This was considered impossible with previous medical technology. Lexiva is a protease inhibitor, which is an antiretroviral medicament or ARV used in treating people with HIV. Studies show that people with HIV over 4 years of age can be given this medicament. Lexiva is commonly used for people with a high viral load and low levels of CD4 Cell Counts. This is used to keep HIV patients healthy with every treatment. The Lexiva capsule is taken orally with a full glass of water. Adults are typically prescribed 1,200mg twice a day. This was first tested using the 150mg capsules that are no longer manufactured today. Considering that the Lexiva capsule is no longer manufactured; patients with HIV can take fosamprevanir as a substitute. Lexiva is approved for use along with ritonavir -- another protease inhibitor medicament. Dosage may include one of the following depending upon the advice of your doctor: 1. 100mg of ritonavir along with 600mg or 4 capsules of Lexiva; twice a day; or 2. 200mg of ritonavir (2 caps) along with 1,200mg (8 caps) of Lexiva; once a day. Common side effects associated with Lexiva include diarrhoea, nausea, emesis, numbness around the mouth, rashes, and stomach pains. A small portion of the patients taking Lexiva suffers from serious skin reactions, such as the Stevens-Johnson syndrome or other allergic reactions to the medicament. Doctors prescribe over-the-counter medicaments to control some of these side effects. If you develop any of these symptoms or other symptoms, consult your doctor immediately. People with an allergic reaction to sulfa medicaments might want to refrain from using Lexiva or seek the advice of a doctor if you plan to proceed with the treatment. Considering that Lexiva is a protease inhibitor, there are no records of problems occurring for people suffering from high-cholesterol levels unlike other medicaments in the same family. Liquid-based Lexiva contains glycol that may cause some problems for infants under 4 years old, people suffering from kidney or liver problems, pregnant women, or those taking certain medicaments. Consult with your doctor if you fall into any of these categories. There is a possibility that Lexiva will react with other medicaments or herbal supplements. Both medicaments in your system may trigger an overdose that could prove fatal to the patient or an underdose that will render the treatment useless. In most cases, other ARV medicaments are said to interact adversely with Lexiva. Patients being treated with tuberculosis medicaments should avoid using this medicament. Medications to treat headaches and migraines, as well as those used for male impotences and to control heart rhythms should be avoided when being treated with Lexiva or vice versa. As with other protease inhibitors, patients planning a treatment using Lexiva must consult with their doctor for a thorough physical and medical examination to avoid risks, as well as following the prescribed dosage to avoid contraindications and fatal reactions.