英文药名: Norprolac (quinagolide Tablets)

中文药名: 喹高莱片

生产厂家: Ferring Pharmaceuticals Inc

药品简介

Norprolac是催乳素抑制剂治疗高泌乳素血症疾病，它是一种由于过量的催乳激素抑制了生产排卵的疾病。
Norprolac作用于垂体块从而抑制生产和催乳素的释放。经过研究，Norprolac的治疗已证明同常规疗法（缩小垂体肿瘤）一样有效的，并且患者的耐受性比常规疗法更好。不能耐受常规疗法的患者往往鼓励使用Norprolac。
高催乳素血症更频繁地发生在孕期妇女, 催乳素的主要职能是加强乳房发育和诱导泌乳。但是，当泌乳素过剩可能抑制促性腺激素的性荷尔蒙，从而影响排卵。除了性功能，高泌乳素血症也会造成一个长期的风险: 骨质疏松症。

包装规格：

150mcg 30 片
   
75mcg 30 片

w does it work?

Norprolac tablets contain the active ingredient quinagolide, which is a type of medicine called a dopamine agonist. It works by stimulating dopamine receptors in the brain.

Quinagolide is used to treat disorders that result from high levels of the hormone prolactin in the blood (hyperprolactinaemia). Prolactin is produced by the pituitary gland in the brain. The pituitary gland may secrete excess prolactin due to a malfunction in the gland, or due to the presence of pituitary tumours (eg prolactin-secreting pituitary microadenoma or macroadenoma).

A high prolactin level (hyperprolactinaemia) can cause several conditions. Over-production of this hormone can cause abnormal production of breast milk in both men and women (galactorrhoea), as well as suppression of the sexual glands (hypogonadism), which can result in infertility. High prolactin levels are also associated with a decreased sex drive and some menstrual disorders. Reducing prolactin levels with quinagolide can therefore improve these conditions.

Quinagolide decreases the production of prolactin from the pituitary by stimulating dopamine receptors in the brain.

What is it used for?

• Hyperprolactinaemia (high blood levels of the hormone prolactin), either with no known cause, or resulting from a tumour in the pituitary gland

Warning!

• Some people may experience dizziness caused by a drop in blood pressure in the first few days of taking this medicine. For this reason, the medicine should be taken at bedtime and the dose is increased gradually using the starter pack. Follow the instructions given by your doctor or pharmacist. It is recommended that your blood pressure is monitored while standing and lying down for a few days after starting treatment and following any dosage increases.
• If you feel dizzy during treatment, this can be relieved by lying down until the symptoms pass. If affected, you should avoid performing potentially hazardous tasks such as driving or operating machinary. Drinking alcohol may increase your likelihood of feeling dizzy.
• This medicine can cause sleepiness. On rare occasions people taking similar medicines to treat Parkinson's disease have experienced a sudden onset of sleep during their daily activities. In some cases this occured without any warning signs. Although this is rare, while taking this medicine you should exercise caution when driving or performing other potentially hazardous activities. People who have experienced sleepiness or a sudden onset of sleep while taking this medicine should not drive or operate machinary. Caution should be observed when drinking alcohol or taking other medicines that cause drowsiness, as this may increase the risk of drowsiness.
• This medicine may restore fertility. Women who could get pregnant but don't wish to should therefore use a reliable method of contraception to prevent pregnancy during treatment. Seek medical advice from your doctor.

Use with caution in

• History of psychotic illness

Not to be used in

• Decreased kidney function
• Decreased liver function
• Breastfeeding

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

• There is no information available about the safety of this medicine during pregnancy. If you get pregnant during treatment this medicine should be stopped, unless it is considered essential by your doctor. Seek medical advice from your doctor.
• This medicine usually suppresses the production of breast milk. However, if lactation should continue when taking this medicine, breastfeeding cannot be recommended as it is not known if the medicine passes into breast milk. Seek medical advice from your doctor.

Label warnings

• Take this medication with or after food.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

• Nausea and vomiting
• Headache
• Dizziness
• Fatigue
• Decreased appetite
• Disturbances of the gut such as diarrhoea, constipation or abdominal pain
• Difficulty in sleeping (insomnia)
• Nasal congestion
• Flushing
• Excessive fluid retention in the body tissues, resulting in swelling (oedema)
• Low blood pressure (hypotension)
• A drop in blood pressure that occurs when moving from a lying or sitting position to sitting or standing, which results in dizziness and lightheadedness (postural hypotension)
• Fainting
• Sleepiness
• Acute psychosis (reversible on stopping treatment)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

Antipsychotic medicines (eg haloperidol, chlorpromazine) may theoretically reduce the prolactin-lowering effect of quinagolide, because these types of medicine work by blocking dopamine receptors.

Other medicines containing the same active ingredient

There are currently no other medicines available in the UK that contain quinagolide as the active ingredient.