英文药名: Caduet(Amlodipine/Atorvastatin Tablets)

中文药名: 氨氯地平阿伐他汀片

生产厂家: Pfizer

药品名称

英文药名: Caduet (Amlodipine/Atorvastatin Tablets)
中文药名: 氨氯地平阿伐他汀片
药品介绍

高血压和高胆固醇是引起心脏病的两个最危险的因素，是全世界最主要的死因之一。2004年1月30日，FDA批准了辉瑞Caduet（复方苯磺酸氨氯地平/阿托伐他汀片）的上市申请。Caduet是首个获准上市的能够同时治疗两种不同疾病（高血压和高胆固醇）的固定剂量复方制剂，它由钙通道阻断剂（CCB）苯磺酸氨氯地平（络活喜）和他汀类降血脂药物阿托伐他汀（立普妥）组成。络活喜和立普妥在各自的相关治疗领域中都领先于其他竞争对手，全球销售额大约为140亿美元。
约有3700名患有高血压和高胆固醇患者施行了Caduet临床研究计划，大多数患者成功的达到正常血压和胆固醇浓度目标。患者对Caduet耐受性好，可与各种抗高血压药（包括噻嗪类利尿药、β-阻滞剂和血管紧张素转化酶抑制剂）同时服用。Caduet最常见的不良反应是体液潴留、头痛、眩晕、腹痛和乏力，均为轻至中度。
Caduet可在任何时间口服，饭前饭后均可。目前上市的片剂有以下剂量：5mg/10mg, 5mg/20mg, 5mg/40mg, 5mg/80mg, 10mg/10mg, 10mg/20mg, 10mg/40mg, and 10mg/80mg。
口服CADUET后，血浆氨氯地平的峰值在服药后6-12小时出现，阿托伐他汀的峰值在1-2小时后出现。服用CADUET后两种活性成分的生物利用度和这两种成分分开服用并没有显著的差异。CADUET 中氨氯地平的生物利用度并不受进食的影响。进食可以降低CADUET 中的阿托伐他汀的吸收率和吸收程度（分别降低32%和11%），但和阿托伐他汀单独服用的降低程度是一样的。另外，进食与否对LDL-C 的降低并没有影响。
Caduet作为治疗成人高血压/心绞痛伴有高血脂的处方药，应与饮食、运动治疗相结合。
Caduet不可用于有肝损害的患者，以及哺乳、妊娠和准备妊娠的妇女。Caduet不能预防心脏病的发作。
最常见的不良反应有水肿、头痛及眩晕，通常是很轻微，会自行消失。在使用Caduet应向医生告知所有服用的药物，这将避免严重的药物之间的互相作用。用药期间应进行血压及肝功能的测量。用药后出现肌肉疼痛及无力的新症状时，应告知医生，这可能是严重副作用的征兆。

Caduet
Generic ingredients: Amlodipine and Atorvastatin
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Why is Caduet prescribed?
Caduet is a combination of two drugs, amlodipine and atorvastatin. It's used for people who need both medications.
Amlodipine is used to treat high blood pressure and angina. Angina is characterized by episodes of crushing chest pain that usually results from a lack of oxygen in the heart muscle due to clogged arteries. Amlodipine is a calcium channel blocker, a type of drug that dilates blood vessels and slows the heart to reduce blood pressure and the pain of angina.
Atorvastatin is a cholesterol-lowering drug. Your doctor may prescribe it along with a special diet if your blood cholesterol or triglyceride level is high enough to put you in danger of heart disease, and you have been unable to lower your readings by diet alone. Atorvastatin works by helping to clear harmful low-density lipoprotein (LDL) cholesterol out of the blood and by limiting the body's ability to form new cholesterol.
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Most important fact about Caduet
You must take Caduet regularly for it to be effective. Caduet does not cure high blood pressure or high cholesterol; it merely helps keep them under control. To get the full benefits of the drug, you should follow any diet, exercise, and weight-loss program prescribed by your doctor.
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How should you take Caduet?
You should take Caduet exactly as prescribed, even if your symptoms improve. Your dosage will be tailored depending on how much of each individual component is needed. The doctor may also direct you to take atorvastatin or amlodipine separately while you're taking Caduet.
Caduet may be taken with or without food.
If you miss a dose.
Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once.
Storage instructions...
Store at room temperature.
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What side effects may occur?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Caduet. Clinical trials have shown no side effect specific to Caduet. Side effects are similar to those reported with amlodipine and atorvastatin.
Side effects of amlodipine may include:
Dizziness, fatigue, flushing, fluid retention and swelling, headache, palpitations (fluttery or throbbing heartbeat)
Side effects of atorvastatin may include:
Abdominal pain, constipation, gas, indigestion
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Why should Caduet not be prescribed?
Never take Caduet during pregnancy or while breastfeeding. Avoid Caduet if you have liver disease, or if the drug gives you an allergic reaction.
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Special warnings about Caduet
There is a slight chance of liver damage from the atorvastatin contained in Caduet. Your doctor may order a blood test to check your liver function before you start taking the drug, again at 12 weeks after you begin therapy or your dosage is increased, and periodically thereafter. If the tests reveal a problem, you may have to stop using the drug.
Drugs like atorvastatin, one of the ingredients in Caduet, have occasionally been known to damage muscle tissue. Be sure to tell you doctor immediately if you notice any unexplained muscle tenderness, weakness, or pain, especially if you also have a fever or feel sick. Your doctor may want to do a blood test to check for signs of muscle damage.
Check with your doctor before you stop taking Caduet. You may need to reduce the dosage slowly.
Your doctor will prescribe Caduet with caution if you have certain heart conditions or liver disease. Make sure your doctor is aware of all your medical problems before you start therapy with Caduet. Although very rare, if you have severe heart disease, you may experience an increase in frequency and duration of angina attacks, or even have a heart attack, when you are starting on Caduet or when your dosage is increased.
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Possible food and drug interactions when taking Caduet
If you take Caduet with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Caduet with any of the following:

Antacids
Cimetidine
Colestipol
Cyclosporine
Digoxin
Erythromycin
Fluconazole
Gemfibrozil
Itraconazole
Ketoconazole
Lipitor, which contains atorvastatin
Niacin
Norvasc, which contains amlodipine
Oral contraceptives
Spironolactone
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Special information if you are pregnant or breastfeeding
Cholesterol-lowering drugs such as Caduet should never be used during pregnancy, since developing babies need plenty of cholesterol. In fact, your doctor is unlikely to prescribe Caduet if there is even a chance that you may become pregnant. If you do conceive while taking Caduet, notify your doctor right away. Caduet does make its way into breast milk, so you should not take Caduet while breastfeeding your baby.
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Recommended dosage for Caduet
Your doctor will base the dosage on how much amlodipine and atorvastatin you're currently taking. Caduet tablets come in doses ranging from 2.5 milligrams amlodipine/10 milligrams atorvastatin up to 10 milligrams amlodipine/80 milligrams atorvastatin. However, a 2.5 milligram/80 milligram Caduet tablet is not available. If your doctor prescribes this dosage combination, you'll need to take each drug separately.
HIGH BLOOD PRESSURE
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Adults
The usual starting dose of amlodipine is 5 milligrams once a day, up to a maximum of 10 milligrams once a day. Individuals who have liver problems and those who are small, fragile, or elderly may be started at 2.5 milligrams a day.
If needed, the doctor may increase your dosage of amlodipine gradually over 1 to 2 weeks depending on how your body responds.
Children 6 to 17 Years Old
The usual dose is 2.5 to 5 milligrams once a day. Doses higher than 5 milligrams daily have not been studied in children.
ANGINA
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Adults
The usual dose of amlodipine is 5 to 10 milligrams once a day. The elderly and individuals with liver problems will usually be started at the 5-milligram dose.

HIGH CHOLESTEROL OR TRIGLYCERIDES
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Adults
The recommended starting dose of atorvastatin is 10 or 20 milligrams once a day. (The doctor may start with 40 milligrams daily if your LDL levels need to be reduced by more than 45 percent.) The doctor will check your cholesterol levels every 2 to 4 weeks and adjust the dose accordingly. The maximum recommended daily dose is 80 milligrams.
Children 10 to 17 Years Old
The recommended starting dose of atorvastatin is 10 milligrams once a day. The dosage may be increased after 4 weeks, as determined by the doctor, up to a maximum of 20 milligrams a day. Girls must be having regular menstrual cycles before starting therapy with atorvastatin.
The safety and effectiveness of atorvastatin in children under 10 years old or in doses greater than 20 milligrams a day have not been studied.
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Overdosage
If you suspect an overdose, seek medical attention immediately. Although no specific information on Caduet overdose is available, any medication taken in excess can have serious consequences.
In addition, no specific information about atorvastatin overdose is available. Experience with amlodipine overdose is limited, but the most likely symptoms include a severe drop in blood pressure and a faster heartbeat.