英文药名: Factive(Gemifloxacin Mesylate Tablets)

中文药名: 甲磺酸吉米沙星片

药品名称

中文通用名称: 甲磺酸吉米沙星
英文通用名称: Gemifloxacin Mesylate
其 它 名 称: Factive, 甲磺酸吉米沙星片, Gemifloxacin Mesylate Tablets, 吉速星
产 品 分 类: 西药\抗感染药\合成抗菌药\喹诺酮类
适应症

1.用于慢性支气管炎急性发作期。
2.用于社区获得性肺炎。
用法用量

成人
*常规剂量
*口服给药
1.慢性支气管炎急性发作期：一次320mg，一日1次，疗程5日。
2.社区获得性肺炎：一次320mg，一日1次，疗程7日。
*肾功能不全时剂量
肌酐清除率大于40ml/min的患者，不需调整剂量。肌酐清除率小于40ml/min的患者，可一次160mg，一日1次。
*肝功能不全时剂量
肝功能不全者(包括Child-Pugh分级为B、C级者)，不需调整剂量。
*透析时剂量
接受血液透析或腹膜透析的患者，可一次160mg，一日1次。
任何疑问，请遵医嘱！
不良反应

1.心血管系统本药可能使QT间期延长，尤其是有QT间期延长史、电解质紊乱、正在使用Ia或III类抗心律失常药物或其它可延长QT间期的药物、心动过缓、急性心肌梗死等患者。
2.中枢神经系统有研究认为本药可引起头痛(1.2%)、眩晕(0.8%)。
3.肝脏有研究认为肝酶升高的发生率为1.3%-4.1%。
4.胃肠道有出现腹泻(3.6%)、恶心(2.7%)、腹痛(0.9%)、呕吐(0.9%)等胃肠道症状的报道。
5.血液葡萄糖-6-磷酸脱氢酶缺乏症患者使用本药时发生溶血的危险增加。
6.皮肤有研究报道皮疹的发生率约2.8%，其中有10%为严重皮疹。皮疹多发生于40岁以下患者(女性为主)，以及使用激素替代治疗的绝经女性，常在服药后8-10日后出现，7日内可缓解。本药引起的光敏反应较少见(有试验认为发生率为0.039%)。
注意事项

1.交叉过敏本药与其它氟喹诺酮类药物可能存在交叉过敏。
2.禁忌症
对本药或其它氟喹诺酮类药物过敏者(国外资料)。
3.慎用
(1)QT间期延长、心动过缓、急性心肌缺血等心脏疾病患者。
(2)葡萄糖-6-磷酸脱氢酶缺乏症患者。
(3)患中枢神经系统疾病者(如癫痫)。
(4)低钾血症及低镁血症者。(以上均为国外资料)
4.药物对儿童的影响18岁以下患者用药的安全性及有效性尚未确定。
5.药物对妊娠的影响国内尚无孕妇用药相关资料。美国药品和食品管理局(FDA)对本药的妊娠安全性分级为C级。
6.药物对哺乳的影响尚不清楚本药是否分泌入乳汁，哺乳妇女用药应权衡利弊。
7.用药前后及用药时应当检查或监测
(1)全血细胞计数及白细胞分类。
(2)细菌培养及药敏试验。
(3)血药浓度监测(尤其是严重感染者)。
(4)尿液分析。
包装规格：

注：以下产品不同规格和不同价格。购买时请以电话咨询为准！

·320mg *5片
·320mg *100 片

Factive Description
This drug is used to treat a variety of bacterial infections. This medication belongs to a class of drugs called quinolone antibiotics. It works by stopping the growth of bacteria.
Factive Directions
Read the Patient Information Leaflet available from your pharmacist. If you have any questions, consult your doctor or pharmacist. Take this medication by mouth with or without food, usually once daily or as directed by your doctor. The dosage and length of treatment is based on your medical condition and response to treatment. Drink plenty of fluids while taking this drug unless your doctor tells you otherwise. Take this medication at least 2 hours before or 3 hours after taking any drugs that contain magnesium or aluminum. Some examples include quinapril, certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), vitamins/minerals, and antacids. Follow the same instructions if you take bismuth subsalicylate, iron, and zinc. Gemifloxacin should be taken at least 2 hours before sucralfate. These medications bind with gemifloxacin and prevent its full absorption. Antibiotics work best when the amount of medicine in your body is kept at a constant level. It is important not to miss a dose. To help you remember, take this medication at the same time every day. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection. Tell your doctor if your condition persists or worsens.
Factive Cautions
Before using gemifloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., ciprofloxacin, levofloxacin); or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of a certain abnormal heart rhythm (long QT interval or QT prolongation), untreated low level of potassium or magnesium in the blood. Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, family history of a certain abnormal heart rhythm (long QT interval or QT prolongation), heart problems (e.g., slow/fast/irregular heartbeat, heart failure, chest pain, recent heart attack), joint/tendon problems (e.g., tendonitis, bursitis), kidney disease, nervous system disorder (e.g., peripheral neuropathy), seizure disorder, conditions that increase your risk of seizures (e.g., brain/head injury, brain tumors, cerebral atherosclerosis). This medication may rarely cause serious changes in blood sugar levels, especially if you have diabetes. Watch for symptoms of high blood sugar including increased thirst and urination. Also watch for symptoms of low blood sugar such as nervousness, shakiness, fast heartbeat, sweating, or hunger. Check your blood sugar regularly as directed by your doctor and report any changes. If you experience symptoms of low blood sugar, you may raise your blood sugar by using glucose tablets/gel or eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor immediately about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. This drug may make you dizzy or lightheaded. Use caution while driving, using machinery, or taking part in any activity that requires alertness. Limit alcoholic beverages. This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors. Caution is advised when using this drug in children because they may be more sensitive to its possible side effects (e.g., joint/tendon problems). Discuss the risks and benefits with the doctor. Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be more sensitive to its side effects such as tendon problems (especially if they are also taking corticosteroids such as prednisone or hydrocortisone) or heart problems. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Factive Side Effects
Nausea, diarrhea, dizziness, lightheadedness, headache, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., anxiety, confusion, hallucinations, depression, rare thoughts of suicide), shaking (tremors), skin that sunburns more easily (sun sensitivity). Tell your doctor immediately if any of these rare but very serious side effects occur: unusual bruising/bleeding, severe/persistent headache, signs of a new infection (e.g., new/persistent fever, persistent sore throat), unusual change in the amount of urine, signs of liver problems (e.g., unusual tiredness, stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine). Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, fainting, fast/irregular heartbeat, seizures. Gemifloxacin may rarely cause serious nerve problems that may be reversible if identified and treated early. Seek immediate medical attention if you develop any of the following symptoms: pain/numbness/burning/tingling/weakness in any part of the body, changes in how you sense touch/pain/temperature/body position/vibration. This medication may rarely cause tendon damage (e.g., tendonitis, tendon rupture) during or after treatment. Stop exercising, rest, and seek immediate medical attention if you develop joint/muscle/tendon pain or swelling. This medication may rarely cause a severe intestinal condition (pseudomembranous colitis) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool. Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms. A very serious allergic reaction to this drug is unlikely. The risk of developing a rash during gemifloxacin treatment is greater in people under age 40, in women, and also in women taking female hormone replacement medication (e.g., estrogens). This risk also increases when gemifloxacin is taken for more than 7 days. Seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: new fever, rash, itching/swelling, severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.