英文药名: Cefzil(Cefprozil Tablets)

中文药名: 头孢丙烯片

品牌药生产厂家: Bristol Meyers Squibb
药品名称

【别名】头孢丙烯 , 施复捷
【外文名】Cefprozil
药理作用

本品为第二代头孢菌素类抗生素，具有广谱抗菌作用，其杀菌的作用机理是阻碍细菌细胞壁的合成。
药代动力学

健康受试者空腹口服头孢丙烯，约95％的给药量可被吸收。空腹服用250mg、500mg或1g后，平均血药浓度为6.1，10.5，和18.3μg/ml，达峰时间为1.5小时。食物与本品同服不影响头孢丙烯的血药峰浓度，但达峰时间可延长0.25-0.75小时。本品的消除半衰期为1.3小时，稳态分布容积约0.23L/kg，蛋白结合率为36％。肾功能减退者，本品的血浆半衰期可处长至5.2小时。血液透析可清除头孢丙烯。肝功能损害者的血浆半衰期可增至2小时左右，但这种改变并不说明肝功能损害者需要调整剂量。
适应症

用于敏感菌所致的下列轻、中度感染：上呼吸道感染（化脓性链球菌性咽炎/扁桃体炎、中耳炎、急性鼻窦炎）。下呼吸道感染（急性支气管炎继发细菌感染和慢性支气管炎急性发作）。皮肤和软组织感染。
用法用量

成人上呼吸道感染，500mg qd,下呼吸道感染500mg bid，皮肤或皮肤软组织感染，250mg bid或500mg qd,严重病例500mg bid.2-12岁的儿童上呼吸道感染，每次7.5mg/kg体重 bid;皮肤或皮肤软组织感染，每次20mg/kg体重 qd；6个月婴儿至2岁儿童中耳炎，每次15mg/kg体重 bid；急性鼻窦炎，一般每次7.5mg/kg体重 bid；严重病例可服用每次15mg/kg体重 bid。疗程一般7-14天，但β-溶血性链球菌所致急性扁桃体炎、咽炎的疗程至少10天。肾功能不全者误码根据肌酐清除率调整剂量：肌酐清除率在30-120ml/分者，按常用剂量、常规时间间隔服药；肌酐清除率为0-29ml/分者，按50％常用剂量，常规时间间隔服药。肝功能受损者无需调整剂量。
任何疑问，请遵医嘱！
不良反应

与其他口服头孢菌素相似，主要为胃肠道反应，如腹泻、恶心、呕吐和腹痛。过敏反应，常见为皮疹、荨麻疹。儿童过敏反应较成人多见，多在开始治疗后几天内出现，停药后几天内消失。
注意事项

对头孢菌素类抗生素过敏者禁用。有青霉素过敏史者服用本品应谨慎。凡以往有青霉素所致过敏性休克史或其他严重过敏反应者不宜使用核武器中。同时报用强利尿剂治疗的患者使用本品应谨慎。
规格

头孢丙烯片剂：250mg/片；500mg/片。
头孢丙烯口服混悬液：125mg/5ml; 250mg/5ml。

Used For

Cefzil (Cefprozil) is a cephalosporin antibiotic that fights bacteria in the body. It is prescribed for the treatment of various types of bacterial infections such as bronchitis, tonsillitis, ear infections, and skin infections.

Directions

For bacterial infections, the recommended dose for adults and teenagers is 250 or 500 milligrams (mg) every 12 to 24 hours for 10 days. Children between 2 to 12 years of age can be administered 7.5 to 20 mg per kilogram (kg) (3.4 to 9.09 mg per pound) of body weight every 12 to 24 hours for 10 days. The recommended dose for infants and children 6 months to 12 years of age is 7.5 to 15 mg per kg (3.4 to 6.81 mg per pound) of body weight every 12 hours for 10 days. For infants below 6 months of age, dose and administration of Cefzil should be determined by the doctor.

How It Works

Cefzil should not be taken by patients who have a history of an allergic reaction to another cephalosporin or a penicillin. Patients with kidney disease, or a gastrointestinal (digestive) disease such as colitis should get proper medical advice before starting on this medication. Cefzil oral suspension contains 28 mg of phenylalanine per teaspoon (5 mL) of suspension for both the 125 mg/5 mL and 250 mg/5 mL dosage strengths. Individuals with phenylketonuria may require monitoring of intake of phenylalanine.

Side Effects

The most severe side effects of Cefzil that require immediate medical attention include rashes, redness, or itching; severe nausea, vomiting, or diarrhea; mucous or blood in the stool; or unusual bleeding or bruising. Other lesser side effects like mild nausea or diarrhea, or yeast infection of the mouth or vagina are more likely to occur during treatment with Cefzil.

Other Info

Tablets maybe split and taken at half the dose. The tablets should be stored at room temperature away from moisture and heat while the suspension should be stored in the refrigerator. Any unused medication older than 14 days should be discarded. There are no restrictions on food, beverages, or activities during treatment with Cefzil unless otherwise directed by your doctor.