塞替派：Thiotepa 
中文别名： 
塞替派、塞替哌、三胺硫磷、三乙撑硫代磷酰胺、三乙烯硫代磷酰胺、噻替哌
英文别名： 
Ledertepa、Tespamin、Thiofosyl、Thiophosphoramide、Thiophosphoramidum、Thiotepum、Triethylene   
药品类别：  烷化剂抗肿瘤药 
 
药理药动
药效学
塞替派为细胞周期非特异性药物，在生理条件下，形成不稳定的亚乙基亚胺基，具有较强的细胞毒作用。塞替派干扰 DNA和 RNA的功能，也能与 DNA发生交叉联结。
药动学
注射后广泛分布在各组织内。主要通过肾脏排泄。
适 应 症
主要用于乳腺癌、卵巢癌、癌性体腔积液的腔内注射以及膀胱癌的局部灌注等，也可用于原发性肝癌、子宫颈癌、胃肠道癌和黑色素瘤等。
用法用量
(1)静脉或肌内注射：一次 10mg(0.2mg/kg)，用氯化钠注射液溶解，每日一次，连续 5次后改为每周 3次，一疗程总量 300mg，如血象良好，在第一疗程结束后 1.5— 2月可重复疗程。
(2)胸腹腔或心包腔内注射：一次 10— 30mg，每周 1一2次。
(3)动脉注射：一次 10— 20mg，每日 1次，总量 200— 300mg。
(4)膀胱腔内灌注：每次排空尿液后将导尿管插入膀胱腔内，再自导尿管内注入塞替派 50一 100mg(溶于 50一 100ml氯化钠注射液中)，每周 1一 2次，10次为一疗程。
[制剂与规格]注射用塞替派(1) 5mg(2) 10mg

(1). 肌注或静注,每次每平方米6mg,成人每次10mg,一日1次,连用5日后改每周3次.也有一次20-30mg,1-2周注射1次,总量200-300mg为一疗程.如血象良好,第一疗程1.5-2月后,按需可再作治疗.
(2).胸腹腔及心包腔内注射,每次10-50mg,每周1-2次,注射前尽量抽出积液.
(3).动脉注射或区域性灌注,每次10-20mg.
(4). 肿瘤内注射,单处或多处注射,每次不超过10mg.
(5).膀胱内灌注,每次60mg,用30-60ml生理盐水或注射用水溶解. 将尿排空后经导尿管注入,变换体位,保留2小时,每周1次,4周后改为每月1次,共10次.
不良反应
骨髓抑制是最常见的剂量限制毒性，多在用药后 1一 6周发生，停药后大多可恢复。有些病例在疗程结束时开始下降，少数病例抑制时间较长。其他可有食欲减退、恶心及呕吐等，个别有发热及皮疹。
骨髓抑制,白细胞及血小板减少.可引起胃肠道反应,恶心呕吐,食欲不振,腹泻.个别病例有药热, 皮疹.
禁忌症
 (1)妊娠初期的 3个月应避免使用此药，因其有致突变或致畸胎作用，可增加胎儿死亡及先天性畸形。
(2)下列情况应慎用：骨髓抑制、有痛风病史、肝功能损害、感染、肾功能损害、肿瘤细胞浸润骨髓、有泌尿系结石史。
药物相互作用
(1)塞替派可增加血尿酸水平，为了控制高尿酸血症可给予别嘌醇。
(2)与放射同时应用时，应适当调整剂量。
(3)与琥珀胆碱同时应用可使呼吸暂停延长，在接受塞替派治疗的病人，应用琥珀胆碱前必须测定血中假胆碱酯酶水平。
(4)与尿激酶同时应用可增加塞替派治疗膀胱癌的疗效，尿激酶为纤维蛋白溶酶原的活化剂，可增加药物在肿瘤组织中的浓度。

GENERIC NAME: THIOTEPA - INJECTION (thigh-oh-TEP-uh)

BRAND NAME(S): Thioplex

USES: Thiotepa is used to treat cancer. It works by slowing or stopping the growth of cancer cells. Thiotepa is often given into the bladder to treat bladder cancer.

HOW TO USE: This medication is given by injection into a vein by a health care professional, usually once a week or as directed by your doctor. Sometimes, thiotepa is injected directly into the tumor. Tell your doctor or nurse immediately if you experience pain, burning, or redness at the injection site.For treatment of bladder cancer, thiotepa is usually given into the bladder through a tube (catheter). Your doctor may direct you to limit fluids for 8 to 12 hours before the medication is given. The solution is usually left in place for 2 hours and then drained out through the bladder tube. Your doctor may direct you to change positions every 15 minutes while the solution is in your bladder to make sure the solution treats all parts of your bladder.The dosage and how often the medication is given is based on your medical condition and response to treatment. Your doctor will do blood tests (complete blood count) to find the right dose for you. Your next dose may need to be rescheduled if your white blood cell count or platelets are too low.Learn how to handle, use, and discard chemotherapy and medical supplies safely. Consult your pharmacist. Wear gloves and wash your hands carefully after handling this drug. Avoid getting this medication in your eyes or on your skin. If the medication gets in your eye, wash the affected eye(s) well with water and contact your doctor. If the medication gets on your skin, wash the area well with soap and water.

SIDE EFFECTS: Pain/redness at the injection site, dizziness, headache, blurred vision, fever, nausea, vomiting, stomach/abdominal pain, or loss of appetite may occur. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. In some cases, drug treatment may be necessary to prevent or relieve nausea and vomiting. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Temporary hair loss is another common side effect. Normal hair growth should return after treatment has ended.Many people using this medication have serious side effects. However, remember that your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.Painful sores on the lips, mouth, and throat may occur. To decrease the risk, limit hot foods and drinks, brush your teeth carefully, avoid using mouthwash that contains alcohol, and rinse your mouth frequently with cool water.This medication can lower the body's ability to fight an infection. Tell your doctor promptly if you develop any signs of an infection such as fever, chills, or persistent sore throat.This medication may also cause very serious bleeding. Tell your doctor immediately if any signs of serious bleeding occur, including: easy bruising/bleeding, bloody/black/tarry stools, coughing up blood, nosebleeds that are frequent or hard to stop, dizziness/fainting, fast/irregular heartbeat, pale/gray/bluish skin, unusual tiredness/weakness, vomit that is bloody or looks like coffee grounds.Tell your doctor right away if you have any serious side effects, including: severe stomach/abdominal pain, lower back/side pain, painful/difficult urination, pink/dark urine.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using thiotepa, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially: bone marrow problems (e.g., low white blood cell count/platelets from previous chemotherapy/radiation treatment), kidney disease, liver disease.Wash your hands well to prevent the spread of infections. Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.Before having surgery, tell your doctor or dentist that you are using this medication.This medication is not recommended for use during pregnancy. It may harm the unborn baby. If you become pregnant or think you may be pregnant, tell your doctor immediately. Males and females must use 2 reliable forms of birth control (e.g., condoms and birth control pills) during treatment with this drug. Talk with your doctor about effective forms of birth control.It is not known whether this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: aspirin and other NSAIDs (e.g., ibuprofen), drugs that may harm the immune system (e.g., chemotherapy, corticosteroids such as prednisone), live virus vaccines (e.g., oral polio vaccine, flu vaccine inhaled through the nose), nalidixic acid.Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin) that may increase your risk of bleeding. Low-dose aspirin should be continued if prescribed by your doctor for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day). Consult your doctor or pharmacist for more details.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Laboratory and/or medical tests (e.g., complete blood counts, kidney tests, liver tests) should be performed while you are being treated with the medication and for several weeks after your last dose to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. Keep all medical/lab appointments. If you miss a dose, contact your doctor to establish a new dosing schedule.

STORAGE: Not applicable. This medication is given in a clinic and will not be stored at home.MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).
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【原产地英文商品名】THIOPLEX-15mg/Vial,5Vials/Box
【原产地英文药品名】THIOTEPA
【中文参考商品译名】
注：以下产品不同的规格和不同的价格，购买时请以电话咨询为准！
·塞替派-15毫克/瓶
·塞替派粉针剂
·塞替派-15毫克/瓶, 5瓶/盒
【中文参考药品译名】息安的宾
【中文参考化合物名称】三乙烯硫代磷酰胺
【生产厂家英文名】Lederle Laboratories