英文药名：Nexium Capsules（Esomeprazole Magnesium Hydrate） 中文药名：埃索美拉唑镁胶囊 生产厂家：阿斯利康有限公司 治疗类别名称 质子泵抑制剂 埃索美拉唑是奥美拉唑的S-旋光异构体,是全球首个异构体质子泵抑制剂(PPI),通过特异性抑制胃壁细胞质子泵减少胃酸分泌。经大量临床实验和药物研究证实:其维持胃内pH>4的时间更长,抑酸效率更高,疗效优于前两代PPI，个体差异小。作为新一代PPI,现已广泛应用于临床治疗诸多酸相关疾病。 ネキシウムカプセル10mg／ネキシウムカプセル20mg 商標名 Nexium Capsules 一般名：エソメプラゾールマグネシウム水和物（Esomeprazole Magnesium Hydrate）(JAN) 化学名：Bis{5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-benzimidazol-1-yl}monomagnesium trihydrate 構造式： 分子式：C34H36N6O6S2Mg・3H2O 分子量：767.17 融点：約170℃ 性状： 埃索美拉唑镁水合物是一种白色非常浅灰色或非常浅黄色粉末 适应病症 ○胃食管反流病(GERD) －反流性食管炎的治疗 －已经治愈的食管炎患者预防复发的长期治疗 －胃食管反流病(GERD)的症状控制 与适当的抗菌疗法联合用药根除幽门螺杆菌，并且 －愈合与幽门螺杆菌相关的十二指肠溃疡 －预防与幽门螺杆菌相关的消化性溃疡复发 ○需要持续NSAID治疗的患者 －与使用(非甾体抗炎药)NSAID治疗相关的胃溃疡治疗 用法用量 口服，不可咀嚼或倾出内容物。 ○胃食管反流病(GERD) －反流性食管炎的治疗 40mg每日一次，连服四周。 ○对于食管炎未治愈或持续有症状的患者建议再服药治疗四周。 －已经治愈的食管炎患者预防复发的长期治疗 20mg每日一次。 －胃食管反流病(GERD)的症状控制 没有食管炎的患者20mg每日一次。如果用药4周症状未获控制，应对患者作进一步的检查。一旦症状消除，随后的症状控制可采用按需疗法，即需要时口服20mg，每日一次。对于使用NSAID治疗有发生胃及十二指肠溃疡危险的患者，随后的症状控制不推荐按需治疗。 ○与适当的抗菌疗法联合用药根除幽门螺杆菌，并且 －愈合与幽门螺杆菌相关的十二指肠溃疡 －预防与幽门螺杆菌相关的消化性溃疡复发 本品20mg+阿莫西林1g+克拉霉素500mg，每日二次，共7天。 ○需要持续NSAID治疗的患者 -与使用NSAID治疗相关的胃溃疡的治疗：常用剂量每日一次20mg，4～8周。 药效药理 ○在人类的影响 在胃pH效应 在健康的成年人，埃索美拉唑10mg，每日的时间由20毫克和40毫克剂量显示在24小时内胃内pH的百分比是4个或更多，分别为48±23％，62±14％和68±8％ ○非临床研究 质子泵抑制剂 胃粘膜衍生质子泵（H +K + -ATP酶）显示上的抑制作用。 ○抑制胃酸分泌作用 它表现出对离体兔胃腺胃酸生产的抑制作用。在胃瘘大鼠的Heidenhain袋狗，它显示对诱发胃酸分泌到兴奋剂的抑制作用。埃索美拉唑，这是这种药物，这是奥美拉唑的光学异构体中的一个的活性成分是一种外消旋的（S体）。 ○作用机理 由各种酸分泌刺激剂，以存在于细胞膜胃壁细胞的受体结合，一系列胃酸分泌反应的发生在胃壁细胞。在反应中，由胃壁细胞释放的H+的最后过程中，它是工作酶称为掺入钾代替质子泵。埃索美拉唑，通过抑制该质子泵的作用，抑制胃酸分泌。 包装规格 胶囊 10毫克：[PTP]100胶囊（10粒×10），140胶囊（14粒×10），500胶囊（10粒×50），700胶囊（14粒×50）[瓶装]500胶囊 20毫克：[PTP]100胶囊（10粒×10），140胶囊（14粒×10），500胶囊（10粒×50），700胶囊（14粒×50）[瓶装]500胶囊 制造厂商 阿斯利康有限公司 Nexium Capsules（Esomeprazole Magnesium Hydrate） Nexium Capsules 10（ネキシウムカプセル10mg）  Brand name : Nexium Capsules 10 　Active ingredient: Esomeprazole 　Dosage form: grayish purple/light yellow capsule, major diameter 11.4 mm, minor diameter 4.90 mm 　Print on wrapping: surface/ネキシウム10,backside/ネキシウム10mg Nexium Capsules 20（ネキシウムカプセル20mg） Brand name : Nexium Capsules 20 　Active ingredient: Esomeprazole 　Dosage form: deep blue/slightly yellow red capsule, major diameter 11.4 mm, minor diameter 4.90 mm 　Print on wrapping: surface/ネキシウム20, backside/ネキシウム20mg Effects of this medicine This medicine acts on a terminal step in gastric acid secretion, called " proton-pump", and inhibits gastric acid secretion. Usually, used for treatment of gastric/anastomotic/duodenal ulcer, reflux esophagitis, non-erosive gastroesophageal reflux disease, Zollinger-Ellison syndrome, and for suppression of recurrence of gastric/duodenal ulcer associated with nonsteroidal anti-inflammatory drug or low-dose aspirin medication. Other purposes, this medicine enhances antimicrobial activity of antimicrobial drugs by elevating pH in the stomach via inhibition of the gastric-acid secretion, used for eradication of Helicobacter pylori in the stomach in gastric ulcer/duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, after endoscopic therapy for early gastric cancer, Helicobacter pylori gastritis with 2 other antibacterial drugs. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. •If you have liver disorder. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •To treat gastric/anastomotic/duodenal ulcers, Zollinger-Ellison syndrome: In general, for adults, take 2 capsules (20mg of the active ingredient) at a time, once a day. The usual duration of administration is up to 8 weeks for gastric/anastomotic ulcers , and up to 6 weeks for duodenal ulcer. To treat reflux esophagitis: In general, for adults, take 2 capsules (20mg of the active ingredient) at a time, once a day. The usual duration of administration is up to 8 weeks. For maintenance therapy of repeatedly recurrent/relapsing reflux esophagitis, take 1-2 capsules (10-20mg of the active ingredient) at a time, once a day. To treat non-erosive gastroesophageal reflux disease: In general, for adults, take 1 capsule (10mg of the active ingredient) at a time, once a day. The usual duration of administration is up to 4 weeks. For suppression of recurrence of gastric/duodenal ulcer associated with nonsteroidal anti-inflammatory drug or low-dose aspirin medication: In general, for adults, take 2 capsules (20mg of the active ingredient) at a time, once a day. For eradication of Helicobacter pylori: In general, for adults, take 2 capsules (20mg of the active ingredient) concomitantly with 750 mg of amoxicillin hydrate(titer) and 200 mg or 400 mg of clarithromycin(titer) at a time, twice a day, for 7 days. If this is insufficient, as an alternative, take 2 capsules (20 mg of the active ingredient) concomitantly with 750 mg of amoxicillin hydrate(titer) and 250 mg of metronidazole(titer) at a time, twice a day for 7 days. Strictly follow the instructions. •If you miss a dose, take a dose as soon as possible when you remember that you have missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine • Possible adverse reactions to this medicine The most commonly reported adverse reactions include diarrhea, liver function abnormality, erosive gastritis, abdominal distension, gastric polyps, anemia, rash, soft stool and taste disorder. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •respiratory distress, urticaria, facial/lips/tongue swelling  [shock, anaphylactoid symptoms] •body dullness, fever, nose bleeding/subcutaneous hemorrhage  [pancytopenia, agranulocytosis, thrombocytopenia] •nausea, vomiting, loss of appetite, yellowing in the skin or white of the eye  [fulminant hepatitis, hepatic dysfunction, jaundice, hepatic failure] •fever, general malaise, rash on the skin/eyes and in mouth  [toxic epidermal necrolysis, mucocutaneous-ocular syndrome] •fever, cough, breathlessness  [interstitial pneumonia] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of reach of children. Store away from heat, humidity and direct sunlight. •Discard remaining medicine; do not store them. AstraZeneca K.KInternal Revised: 5/2013 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. http://meds.qlifepro.com/detail/622080701/nexium-capsules-10-mg