部分中文必康平处方资料（仅供参考）
药品英文名
Telmisartan
药品别名
美卡素、泰米沙坦、Micardis
药物剂型
1.片剂：80mg；40mg；20mg；
2.胶囊：400mg。
药理作用
本品为非肽类ARB，其化学结构为非联苯四唑类，竞争性或混合性拮抗AT1受体，且结合具有高度选择性和不可逆性。替米沙坦对AT1受体的亲和力远高于AT2受体约3000倍。
药动学
口服吸收迅速，血药浓度在服药后30～60min达到峰值，进食轻度减少其生物利用度。本品绝对生物利用度呈剂量依赖性，平均为50%。与血浆蛋白高度结合达99.5%。药物几乎完全(97%)以原形经粪便排泄，仅有少量从尿液排出。
适应证
高血压。
禁忌证
对该药活性成分及任何一种赋形成分过敏者；妊娠及哺乳期妇女；胆道阻塞疾病；严重肝肾功能不全禁用。
注意事项
1.慎用：
(1)双侧或单侧功能肾肾动脉狭窄者；
(2)血容量不足(包括因强利尿药治疗、限盐饮食、恶心或呕吐引起血容量不足或血钠水平过低)者；(3)严重充血性心力衰竭(可能引起急性低血压、氮质血症、少尿或罕见急性肾衰竭)者；(4)主动脉瓣狭窄或左房室瓣狭窄；
(5)肥厚型心肌病；
(6)冠状动脉疾病患者；
(7)血管神经性水肿患者；
(8)需进行全身麻醉手术者；
(9)老年患者。
2.肾功能不全患者用药期间应定期检测血钾水平及血肌酐值。
3.治疗期间如发生低血压，应采取相应的支持治疗。
4.本药不能经血液透析清除，血液透析患者在治疗初期应注意监测，以防发生直立性低血压。5.突然停药，血压可在数日后逐渐恢复到治疗前水平，而不出现反弹性高血压。
6.抑制肾素-血管紧张素-醛固酮系统的抗高血压药通常对原发性醛固酮增多症患者无效，故不推荐本药用于该类患者。
7.应用本药4～8周后才发挥最大药效，在加大剂量时应注意此点。
不良反应
头晕、头痛、恶心、腹泻及血管神经性水肿等，咳嗽的发生率明显低于ACEⅠ。
用法用量
高血压患者服用替米沙坦后3h即表现出降压效果，4周降压作用最强，停药后数日至1周血压逐渐恢复到基础水平。用药范围为每天20～80mg，在此范围内其降压疗效呈剂量依赖性。老年人轻至中度肾功能不全的患者无需调整药物剂量；轻、中度肝功能不全者每天用药不应超过40mg。
药物相应作用
替米沙坦与地高辛合用时，可使后者的血药浓度升高，因此合用时应调整剂量；与华法林合用10天，可轻微降低后者的平均谷浓度；与氨氯地平、氢氯噻嗪、格列本脲和布洛芬合用未见有临床意义的相互作用；此外，该药不被细胞色素P450系统代谢，也不影响细胞色素P450系统。

MicardisGeneric Name: telmisartan (Oral route)
tel-mi-SAR-tan
Oral routeTablet
When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, telmisartan tablets should be discontinued as soon as possible .
Drugs that act directly on the renin-angiotensin system can cause injury or death to the developing fetus when used during the second and third trimesters. Stop therapy as soon as possible when pregnancy is detected .
Commonly used brand name(s):
In the U.S.
Micardis
Available Dosage Forms:
Tablet
Therapeutic Class: Cardiovascular Agent
Pharmacologic Class: Angiotensin II Receptor Antagonist
Uses For Micardis
Telmisartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Telmisartan is also used to lower the risk of heart attack or stroke in patients older than 55 years of age who have been diagnosed with diabetes or heart or blood vessel problems.
Telmisartan is an angiotensin II receptor blocker. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, telmisartan relaxes blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
This medicine is available only with your doctor's prescription.
Before Using Micardis
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of telmisartan in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of telmisartan in the elderly.

Pregnancy

	Pregnancy Category	Explanation
1st Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
3rd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Ramipril
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Aceclofenac
Acemetacin
Alclofenac
Apazone
Benoxaprofen
Bromfenac
Bufexamac
Carprofen
Celecoxib
Clometacin
Clonixin
Dexketoprofen
Diclofenac
Diflunisal
Digoxin
Dipyrone
Droxicam
Etodolac
Etofenamate
Felbinac
Fenbufen
Fenoprofen
Fentiazac
Floctafenine
Flufenamic Acid
Flurbiprofen
Ibuprofen
Indomethacin
Indoprofen
Isoxicam
Ketoprofen
Ketorolac
Lithium
Lornoxicam
Meclofenamate
Mefenamic Acid
Meloxicam
Nabumetone
Naproxen
Niflumic Acid
Nimesulide
Oxaprozin
Oxyphenbutazone
Phenylbutazone
Pirazolac
Piroxicam
Pirprofen
Propyphenazone
Proquazone
Rofecoxib
Sulindac
Suprofen
Tenidap
Tenoxicam
Tiaprofenic Acid
Tolmetin
Valdecoxib
Zomepirac
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Aortic valve damage—Risk of decreased blood flow through the heart.
Dehydration (fluid and electrolyte loss due to excessive perspiration, vomiting, diarrhea, prolonged diuretic therapy, dialysis, or dietary salt restriction) or
Heart failure or other heart problems (e.g., coronary artery disease) or
Hyponatremia (low sodium in the blood)—Use with caution. The blood pressure–lowering effects of telmisartan may be increased.
Kidney disease or
Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use of Micardis
In addition to the use of this medicine, treatment for your high blood pressure may include weight control and a change in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.
Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.
Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.
This medicine also works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at the same time each day.
This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.
You may take this medicine with or without food.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (tablets):
For high blood pressure:
Adults—At first, 40 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 80 mg.
Children—Use and dose must be determined by your doctor.
To lower the risk of heart or blood vessel problems:
Adults 55 years of age and older—80 milligrams (mg) once a day.
Children—Use and dose must be determined by your doctor.
Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Protect the tablets from moisture and do not remove from the blister pack until you are ready to use them.
Precautions While Using Micardis
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away.
Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.
Dizziness, lightheadedness, or fainting may occur after the first dose of this medicine, especially if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.
Dizziness, lightheadedness, or fainting may also occur if you exercise or when the weather is hot. Heavy sweating may cause you to lose too much water or salt which may cause low blood pressure. Use extra care during exercise or hot weather.
Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt which may cause low blood pressure.
Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeat; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.
Micardis Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Changes in vision
dizziness, lightheadedness, or fainting
fast heartbeat
large hives
Incidence not known
Blurred vision
chest pain or discomfort
confusion
dark-colored urine
decreased urine output
difficult breathing
dilated neck veins
extreme fatigue
fast or irregular heartbeat
flushing
hives or welts
hoarseness
irregular breathing
irritation
itching
joint pain, stiffness, or swelling
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
muscle cramps or stiffness
numbness or tingling in the hands, feet, or lips
pain or discomfort in the arms, jaw, back, or neck
pounding in the ears
rash
redness of the skin
shortness of breath
slow or fast heartbeat
sweating
swelling of the eyelids, face, or lips
tightness in the chest
troubled breathing or swallowing
trouble with speaking or walking
trouble with thinking
unusual tiredness or weakness
unusually warm skin
weakness or heaviness of the legs
weakness, numbness or tingling in the arms or legs
weight gain
wheezing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Abdominal or stomach pain
back pain
bloating or gas
changes in appetite
coughing, ear congestion or pain, fever, head congestion, nasal congestion, runny nose, sneezing, or sore throat
diarrhea
dry mouth
general tiredness or weakness
headache
heartburn
increased sweating
muscle pain or spasm
nausea
nervousness
painful urination or changes in urinary frequency
skin rash
swelling in the hands, lower legs, and feet
Incidence not known
Acid or sour stomach
belching
decreased interest in sexual intercourse
difficulty with moving
inability to have or keep an erection
indigestion
joint pain
lack or loss of strength
leg cramps
loss in sexual ability, desire, drive, or performance
muscle aching
stomach discomfort, upset or pain
swelling
weakness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

附件:
2010112918333322.pdf

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注：以下产品不同规格不同价格，购买以咨询为准！
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产地国家: 土耳其
原产地英文商品名:
MICARDIS 80mg/tab 28tabs/box
原产地英文药品名:
TELMISARTAN
中文参考商品译名:
必康平 80毫克/片 28片/盒
中文参考药品译名:
替米沙坦
中文参考化合物名称:
4＇-[(1，4＇-二甲基-2＇-丙基[2，6＇-二-1H-苯并咪唑]-1＇-基)甲基]-[1，1＇-二联苯基]-2-羧酸
生产厂家中文参考译名:
勃林格殷格翰
生产厂家英文名:
BOEHRINGER INGELHEIM
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产地国家: 澳大利亚
原产地英文商品名:
MICARDIS 40mg/tab 28tabs/box
原产地英文药品名:
TELMISARTAN
中文参考商品译名:
必康平 40毫克/片 28片/盒
中文参考药品译名:
替米沙坦
中文参考化合物名称:
4＇-[(1，4＇-二甲基-2＇-丙基[2，6＇-二-1H-苯并咪唑]-1＇-基)甲基]-[1，1＇-二联苯基]-2-羧酸
生产厂家中文参考译名:
勃林格殷格翰
生产厂家英文名:
BOEHRINGER INGELHEIM
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产地国家: 英国
原产地英文商品名:
MICARDIS 20mg/tab 28tabs/box
原产地英文药品名:
TELMISARTAN
中文参考商品译名:
必康平 20毫克/片 28片/盒
中文参考药品译名:
替米沙坦
中文参考化合物名称:
4＇-[(1，4＇-二甲基-2＇-丙基[2，6＇-二-1H-苯并咪唑]-1＇-基)甲基]-[1，1＇-二联苯基]-2-羧酸
生产厂家中文参考译名:
勃林格殷格翰
生产厂家英文名:
BOEHRINGER INGELHEIM
该药品相关信息网址1:
http://www.ontarget-micardis.com/
该药品相关信息网址2:
http://www.drugs.com/micardis.html