肝宁组合片（PROHEPARUM Combination Tab）-科研制药的首个保肝新药
欧文商標名
PROHEPARUM Combination Tab
通用名：肝宁组合片
组成
有效成分
I包含以下成分的1片。
肝水解物70mg的
半胱氨酸盐酸盐20毫克
酒石酸氢胆碱100毫克
肌醇25毫克
日本药典氰钴胺1.5μg
*添加剂
小麦淀粉，乳糖一水合物，明胶，液体石蜡，硬脂酸镁，滑石粉，轻质无水硅酸，氢化油，精制白糖，沉淀碳酸钙，羟丙甲纤维素，阿拉伯胶，柠檬酸三乙酯，巴西棕榈蜡，有机硅树脂，三氧化二三价铁，黑色氧化铁，黄色，蓝色2号，药用炭
性状
这是一个椭圆形的棕色，糖衣片。
效果或疗效
慢性肝病中的肝功能改善
用法与用量
口服给药，一日三次一次，每次1-2片
药理
以下的效果已被观察到肝水解物的（肝水解产物） 。
（1）为了促进肝组织呼吸衰竭大鼠在四氯化碳中（体外）
（2）(IM )部分肝切除大鼠肝蛋白质合成的能力，以提高。
（3）以提高酒精性肝衰竭大鼠肝脏蛋白质合成的能力，降低了肝脏的中性脂肪（口服）。
（4）在人类肝硬化，导致减少的γ-球蛋白与白蛋白（Ⅳ）增加。
（5）为了促进部分肝切除大鼠肝细胞中的线粒体中ATP的产生，从而提高能力，合成DNA （IM）。
（6）徒晋升到BSP大鼠肝细胞排泄机制，促进胆汁排泄（四） 。
（7）抑制在四氯化碳衰竭大鼠的脂肪量和肝胶原蛋白含量增加，从而提高了酶的酶活性肝（肌内）。
（8）在人类慢性肝炎，肝硬化，显着增加肝脏的血流量速率（IM） 。
包装
PTP: 100， 1,000， 2,100片
瓶: 100， 500粒
生产厂家
科研制药有限公司
完整资料附件：http://www.info.pmda.go.jp/go/pack/3919101F1031_1_01/
プロヘパール配合錠
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name : PROHEPARUM Combination Tablets
Active ingredient: Liverhydolysate, Cysteine hydrochloride, Choline bitartrate, Inositol, Cyanocobalamin
Dosage form: dark brown oval tablets, major axis 15.6 mm, minor axis 11.7 mm, thickness 7.0 mm
Print on wrapping: プロヘパール配合錠,PROHEPARUM Combination Tab.,KC33
Effects of this medicine
This medicine prompts the synthesis of protein in liver and increases the amount of hepatic blood flow, thus enhances liver function and improves the decreased liver function.
It is usually used to improve liver function in chronic liver disease.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are patients with hepatic coma.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>>
•In general, for adults, take 1-2 tablets at a time, three times a day. Strictly follow the instructions.
•If you miss a dose, take the missed dose as soon as possible. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
• Possible adverse effects of this medicine
The most commonly reported adverse reactions include rash, urticaria, nausea, stomach distension, headache and facial flush. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
•If any medicine is left, do not store them. You must discard the remainder.