neric Name for TRIOSTAT
Liothyronine (as sodium) 10mcg/mL; soln for IV inj.
Legal Classification:
Rx
Pharmacological Class for TRIOSTAT
T3 (synthetic).
Manufacturer of TRIOSTAT
JHP Pharmaceuticals
Indications for TRIOSTAT
Myxedema coma/precoma.
Adult dose for TRIOSTAT
Give with glucocorticoids. Allow 4–12 hours between doses. Initially 25–50mcg. Cardiovascular disease: initially 10–20mcg. Usual range: 65–100mcg daily. Change to oral therapy as soon as possible: start tabs at low dose and increase gradually; discontinue IV gradually.
Children's dosing for TRIOSTAT
Not recommended.
Contraindications for TRIOSTAT
Uncorrected adrenocortical insufficiency. Untreated thyrotoxicosis. Artificial rewarming.
Warnings/Precautions for TRIOSTAT
Not for treatment of obesity. Cardiovascular disease, angina, elderly: initiate therapy at 10–20micrograms. Severe and prolonged hypothyroidism. Fluid therapy. Adrenocortical insufficiency. Pregnancy (Cat.A). Nursing mothers.
Interactions for TRIOSTAT
Potentiates digitalis toxicity, tricyclic antidepressants, sympathomimetics (e.g., anorectics). May increase risk of coronary insufficiency with vasopressors. Monitor oral anticoagulants, hypoglycemics. Estrogens affect thyroid function tests. May be potentiated by tricyclic antidepressants. Hypertension, tachycardia with ketamine.
Adverse Reactions for TRIOSTAT
Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, MI, angina, CHF, hypertension, twitching.
How is TRIOSTAT supplied?
Vials (1mL)—6
Related Disease:
Hypothyroidism
Myxedema coma
Triostat®
brand of liothyronine sodium injection (T3) PRESCRIBING INFORMATION
【英文名称】 Liothyronine Sodium 碘塞罗宁钠
【其他名称】 三碘甲腺原氨酸钠，T3
【适应证】各种原因引起的甲状腺功能减退症。
【药品分类】内分泌系统用药-甲状腺疾病用药-甲状腺激素[1]
【药理毒理】为人工合成的三碘甲状腺原氨酸钠，作用与甲状腺素相似，其作用是甲状腺素的3-5倍
拟钙剂的副作用：
Triostat DescriptionThyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. T4 contains four iodine atoms and is formed by the coupling of two molecules of diiodotyrosine (DIT). T3 contains three atoms of iodine and is formed by the coupling of one molecule of DIT with one molecule of monoiodotyrosine (MIT). Both hormones are stored in the thyroid colloid as thyroglobulin and released into the circulation. The major source of T3 has been shown to be peripheral deiodination of T4. T3 is bound less firmly than T4 in the serum, enters peripheral tissues more readily, and binds to specific nuclear receptor(s) to initiate hormonal, metabolic effects. T4 is the prohormone which is deiodinated to T3 for hormone activity.
Thyroid hormone preparations belong to two categories: (1) natural hormonal preparations derived from animal thyroid, and (2) synthetic preparations. Natural preparations include desiccated thyroid and thyroglobulin. Desiccated thyroid is derived from domesticated animals that are used for food by man (either beef or hog thyroid), and thyroglobulin is derived from thyroid glands of the hog.
Triostat (liothyronine sodium injection) (T3) contains liothyronine (L-triiodothyronine or L-T3), a synthetic form of a natural thyroid hormone, as the sodium salt.
The structural and empirical formulas and molecular weight of liothyronine sodium are given below.
L-Tyrosine, 0-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt
In euthyroid patients, 25 mcg of liothyronine is equivalent to approximately 1 grain of desiccated thyroid or thyroglobulin and 0.1 mg of L-thyroxine.
Each mL of Triostat in amber-glass vials contains, in sterile non-pyrogenic aqueous solution, liothyronine sodium equivalent to 10 mcg of liothyronine; alcohol, 6.8% by volume; anhydrous citric acid, 0.175 mg; ammonia, 2.19 mg, as ammonium hydroxide.