部分中文Cibenol处方资料（仅供参考）
中文名称 琥珀酸西苯唑啉
【药理作用】 本品为咪唑类衍生物，具有抗心律失常作用，既具Ⅰa类抗心律常药的作用，又有Ⅲ类和Ⅴ类者的特点，即抑制Na+通道，减少Na+内流，降低0相最大上升速率和幅度，减慢传导速度；抑制钾通道，减少K+外流，延长动作电位过时程；抑制Ca2+通道，减少Ca2+内流，减弱心肌收缩力。
【药代动力】 本品口服吸收良好，生物利用度大于90%。服药后1小时血药浓度达峰值。与血浆蛋白的结合率约60%。约60%以原形药物自尿排泄。t1/2为7小时。有效血药浓度0.2～0.4mg/L，超过1.8mg/L则可能中毒。主要以原形经肾排泄，排泄较快，24h可完全排泄，t1/2为7～15h
【适 应 症】常用于防治室性或室上性心律失常，尤多在新发生的心肌梗塞时应用。也用于心房颤动、心房扑动恢复节律后的维持治疗。
【用法用量】苯并/磷酸琥珀酸酯用于成年人，1日300毫克口服给药，一天三次。另外，也将增加或减少取决于患者的年龄和症状。
【不良反应】常见的不良反应有消化道反应、头晕、视力模糊及肝功障碍。长期口服可引起低血糖、低血压。
【注意事项】 禁用于严重心衰、传导阻滞者及孕妇。严重肾功能低下者宜减量。
シベノール錠50mg／シベノール錠100mg
商標名
Cibenol Tablets
一般名
シベンゾリンコハク酸塩（Cibenzoline Succinate）
包装
錠50mg：100錠（10錠×10）
錠50mg：500錠（10錠×50）
錠50mg：1,000錠（10錠×100）
錠50mg：1,000錠（バラ）
錠100mg：100錠（10錠×10）
錠100mg：500錠（10錠×50）
錠100mg：1,000錠（10錠×100）
錠100mg：1,000錠（バラ）
製造販売
アステラス製薬株式会社
完整资料附件：http://www.info.pmda.go.jp/go/pack/2129007F1020_3_11/
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name : Cibenol Tablets 100mg
Active ingredient: Cibenzoline succinate
Dosage form: white tablet (φ: 7.1 mm, thickness: 3.6 mm)
Print on wrapping: (face) シベノール100mg, (back) シベノール100, 100mg, シベンゾリン(Cibenzoline)
Effects of this medicine
This medicine works to normalize the pulse by blocking the sodium channel (membrane-stabilizing action) of cardiac muscle as well as prolonging the action potential duration.It is usually used for the treatment of arrhythmia.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
•If you have heart disease, glaucoma or difficulty in urination.
•If you are on dialysis.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is << to be written by a healthcare professional>>
•In general, for adults, start at a dose of 100 mg as the active ingredient at a time, 3 times a day. If it is ineffective, the dose may be increased up to 150 mg at a time, 3 times a day. The dosage may be adjusted according to the patient's age and symptoms.Each tablet contains 100 mg of the active ingredient. Use this tablet when you take the medicine 100 mg at a time according to your dosage described above. Strictly follow the instructions.
•If you miss a dose, take the dose as soon as you realize you have missed a dose. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule from the next dose onwards. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Dizziness or swaying feeling may occur after taking this medicine. Avoid driving a car, operating machinery or working at heights.
Possible adverse effects of this medicine
The most commonly reported adverse reactions include rash, erythema, feeling of itching, dry mouth, stomach discomfort, and swaying feeling. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•dizziness, chest pain, palpitation[arrhythmogenic activity]
•facial pallor, cold sweat, dizziness on standing up[shock, anaphylaxis]
•shortness of breath, whole-body edema, cough[cardiac failure]
•sweat, chills, palpitation[hypoglycemia]
•general malaise, loss of appetite, yellowing of the skin and the whites of the eyes[liver disorder due to circulatory failure, hepatic function disorder, jaundice]
•fever, dry cough, dyspnoea[interstitial pneumonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of infants and young children. Store away from direct sunlight, heat and humidity.
•Discard the remainder. Do not store them. Consult with your dispensing pharmacy when you discard the medicine.