英文药名：GASMOTIN Powder1%（Mosapride Citrate Hydrate） 中文药名：枸橼酸莫沙必利１％散 日文药名：ガスモチン散１％ 生产厂家：大日本住友制药 类别名称 消化道机能改善剂 枸橼酸莫沙必利为第三代胃动力促进药品，为选择性5-HT4受体激动剂，激动消化道粘膜下神经丛的5-HT4受体，促进乙酰胆碱的释放，从而产生消化道的促动力作用。 商標名 GASMOTIN 化学構造 一般名 モサプリドクエン酸塩水和物 Mosapride Citrate Hydrate 化学名 4-Amino-5-chloro-2-ethoxy-N-{[(2RS)-4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide monocitrate dihydrate 分子式 C21H25ClFN3O3・C6H8O7・2H2O 分子量 650.05 分配係数 9.1×102(クロロホルム/水系溶媒、pH7.0、室温) 性状 它是白色结晶粉末，以黄色。 N，N-二甲基甲酰胺或易溶于乙酸（100），微溶于甲醇，乙醇（99.5）微溶，并且几乎不溶于水。 N，N-二甲基甲酰胺溶液（1→20）示出了没有旋光性。 药效药理 1. 臨床薬理 在胃的健康成人9）和慢性胃炎的患者10）倒空的研究，它显示了胃排空促进这种药物5毫克1次服下作用。 2. 上消化道促动力作用 (1) 胃，十二指肠促动力作用 以剂量依赖的方式，指示胃餐后期间，十二指肠促动力作用（狗）。 (2) 胃排空促进措施 胃排空促进液体产品（小鼠，大鼠）和胃排空促进固体行动行动表明了（鼠）。此外，胃排空促进在一个星期内重复给药动作被衰减（鼠）。 3.下消化道蠕动促进作用 (1) 结肠动力和运输促进作用 结肠运动的和剂量依赖的方式传输的促进效果（豚鼠）的内容。 (2) 清洗在结肠增强效果和水分重量降低效果（在整个肠灌结合的时间） 整个肠灌（Nifurekku混合在用于代理）通过施用以增强在结肠清洗效果，进一步降低了水的重量在结肠中（豚鼠）。 4. 作用机序 本剤是选择性血清素5-HT 4受体激动剂，刺激存在于胃肠道中的内源性神经5-HT 4受体，示出通过增强乙酰胆碱释放上部和下部消化道蠕动作用据信。 临床应用 ○慢性胃炎（胃灼热，恶心和呕吐）相关○胃肠道症状 ○为钡剂灌肠X线检查整肠灌溉辅助与治疗前 用法与用量 ○慢性胃炎（胃灼热，恶心和呕吐）相关○胃肠道症状 成人，每天15毫克，口服分为三个次、饭前或饭后 ○为钡剂灌肠X线检查整肠灌溉辅助与治疗前 成人中，20毫克如在整个肠灌（约180毫升），整个肠灌于口服给药的给药开始的时间莫沙必利的盐。此外，整个肠灌给药，口服给药的少量的水，以20毫克作为莫沙必利盐结束之后。 包装规格： 散装 100g/瓶 ； 500g/瓶 袋装 0.5gx600袋 生产厂家：大日本住友制药 GASMOTIN Powder1%（Mosapride citrate hydrate） GASMOTIN Powder1%（ガスモチン散1%） Brand name : GASMOTIN Powder1% 　Active ingredient: Mosapride citrate hydrate 　Dosage form: white powder medicine 　Print on wrapping: ガスモチン散1%, 5mg/包（0.5g） Effects of this medicine This medicine stimulates serotonin receptor in the digestive tract and increases acetylcholine release in order to improve functions of enterokinesis and gastric emptying. It is usually used to treat heartburn, nausea and vomiting caused by chronic gastritis and adjunctive treatment to the pretreatment with orally gastrointestinal lavage solution for barium enema X-ray examination. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •For the treatment of heartburn, nausea/vomiting associated with chronic gastritis. In general , for adults, take 0.5g (5mg of mosapride citrate) at a time, 3 times a day, before or after meal. Strictly follow the instructions. For the treatment of adjunctive treatment to the pretreatment with orally gastrointestinal lavage solution for barium enema X-ray examination. In general , for adults, take 2g (20mg of mosapride citrate) with the orally gastrointestinal lavage solution (approx. 180mL) at the time of administration of the lavage solution, and take 2g with a small amount of water after administration of the lavage solution. •For heartburn, nausea/vomiting associated with chronic gastritis, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time. •If you accidentally took more than your prescribed dose,consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine • Possible adverse reactions to this medicine The most reported adverse reaction include diarrhea/loose stool, dry mouth, abdominal pain, lassitude, rash, hives, nausea, feeling of fullness, headache, etc. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •generalized fatigability, loss of appetite, yellowness in the skin and the conjunctiva [fulminant hepatitis, liver dysfunction, jaundice] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from heat, moisture and direct sunlight. •Discard the remainder. Do not store them. Sumitomo Dainippon Pharma Co.,Ltd.Internal Revised: 7/2012 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. http://www.info.pmda.go.jp/go/pack/2399010B1034_1_09/