英文药名：L-Cartin FF injection（Levocarnitine） 中文药名：左卡尼汀FF注射液 生产厂家：大冢制药 エルカルチンFF静注1000mg 类别名称 左旋肉碱配方 商標名 L-Cartin FF injection 一般名 レボカルニチン〔Levocarnitine（JAN）〕 化学名 (R)-3-Hydroxy-4-trimethylammoniobutanoate 構造式 分子式 C7H15NO3 分子量 161.20 性状 它是一种白色结晶粉末。这是非常易溶于水，微溶于乙醇（99.5）。它是吸湿的。的水溶液（1→20）的PH值是6.5至8.5。 操作注意事项 被存储在一个地方让儿童接触不到的地方 药理作用 本品是哺乳动物能量代谢中的必需物质，其主要功能是促进脂类代谢，可以使缺血、缺氧时堆积的脂酰辅酶A进入线粒体内，减少其对腺嘌呤核苷酸转位酶的抑制，使氧化磷酸化得以顺利进行。本品静注还可以纠正血液透析患者体内卡尼汀的缺乏，改善营养状态和因卡尼汀缺乏引起的一系列并发症。本品能加速正常心肌脂肪酸的氧化，为心肌ATP提供来源；降低乙酰辅酶A与游离辅酶A的比例，调节丙酮酸的氧化使葡萄糖氧化增加；减轻心脏缺血损伤程度，促进再灌注时心功能恢复，提高运动耐力。此外，本品还能增加NADH细胞色素C还原酶和细胞色素氧化酶的活性、参与某些药物的解毒作用，有效对抗蒽环类及其他抗肿瘤药物的心脏毒性。 适应证 左卡尼汀是一种用途广泛的氨基酸类药物，加本品替补疗法用于长期的血液透析、左卡尼汀缺乏症、肌肉营养不良、心肌病、急性和慢性心肌梗塞形成、心绞痛、三环类抗抑郁药引起的心律失常、老年性痴呆症、早老性痴呆以及机能衰弱。 用法用量 每次血透后推荐起始剂量是 10～20mg／kg，溶于 5一10ml注射用水中， 2～3分钟 1次静脉推注，血浆左卡尼订波谷浓度低于正常（40～50umol／L）立即开始治疗，在治疗第3或第4周时调整剂量（如在血透后5mg／kg）。 包装规格 FF注射液：1000毫克/5毫升×10管[玻璃安瓿] 生产商： 大冢制药有限公司 注：以上中文资料仅供参考，使用以原处方为准！ L-Cartin FF injection（Levocarnitine）エルカルチンFF静注 Brand name : L-CARTIN FF Injection 1000mg 　Active ingredient: Levocarnitine 　Dosage form: colorless to slightly yellow, clear injection 　Print on wrapping:  Effects of this medicine This medicine activates mitochondrial function by improving a carnitine deficient state, and improves the symptoms such as convulsive attack and hypotonia. It is usually used for the treatment of carnitine deficiency. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have renal disorder. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •In general, this medicine is administered by slow intravenous injection or by intravenous drip infusion, at intervals of 3 to 6 hours. For carnitine deficiency that may occur during hemodialysis, the medicine is generally administered by injection into the venous side of the hemodialysis circuit at the end of dialysis. •The injection interval will depend on the type of concomitant medicines that you are taking and your condition. Consult with your doctor regarding the specific dosing schedule. •You may need to take this medicine for a long period of time depending on your symptoms and response. Precautions while taking this medicine • Possible adverse reactions to this medicine The most commonly reported adverse reactions include loss of appetite, diarrhea, loose stools, enlarged feeling of abdomen , facial edema, hematuria, and anemia. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. No pertinent entries. The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information. http://www.info.pmda.go.jp/go/pack/3999436A1025_1_05/ http://www.kegg.jp/medicus-bin/japic_med?japic_code=00061226