英文药名：L-Cartin FF tablets（Levocarnitine） 中文药名：左卡尼汀FF片 生产厂家：大冢制药 エルカルチンFF錠100mg／エルカルチンFF錠250mg 类别名称 左旋肉碱配方 商標名 L-Cartin FF tablets 一般名 レボカルニチン〔Levocarnitine（JAN）〕 化学名 (R)-3-Hydroxy-4-trimethylammoniobutanoate 構造式 分子式 C7H15NO3 分子量 161.20 性状 它是一种白色结晶粉末。这是非常易溶于水，微溶于乙醇（99.5）。它是吸湿的。的水溶液（1→20）的PH值是6.5至8.5。 熔点 约200℃（分解） 操作注意事项 由于该代理的主要成分具有潮解性能，取出片剂从SP填料（铝板）之前服用 药理作用 本品是哺乳动物能量代谢中的必需物质，其主要功能是促进脂类代谢，可以使缺血、缺氧时堆积的脂酰辅酶A进入线粒体内，减少其对腺嘌呤核苷酸转位酶的抑制，使氧化磷酸化得以顺利进行。本品静注还可以纠正血液透析患者体内卡尼汀的缺乏，改善营养状态和因卡尼汀缺乏引起的一系列并发症。本品能加速正常心肌脂肪酸的氧化，为心肌ATP提供来源；降低乙酰辅酶A与游离辅酶A的比例，调节丙酮酸的氧化使葡萄糖氧化增加；减轻心脏缺血损伤程度，促进再灌注时心功能恢复，提高运动耐力。此外，本品还能增加NADH细胞色素C还原酶和细胞色素氧化酶的活性、参与某些药物的解毒作用，有效对抗蒽环类及其他抗肿瘤药物的心脏毒性。 适应证 左卡尼汀是一种用途广泛的氨基酸类药物，加本品替补疗法用于长期的血液透析、左卡尼汀缺乏症、肌肉营养不良、心肌病、急性和慢性心肌梗塞形成、心绞痛、三环类抗抑郁药引起的心律失常、老年性痴呆症、早老性痴呆以及机能衰弱。 用法用量 成人，每天1.5-3G到3倍。该剂量可以适当地调整根据患者的病情。 儿童，除以体重每天1公斤25-100毫克口服给药3次。该剂量可以适当地调整根据患者的病情。 包装规格 片剂： 100毫克 100片（10片×10），500片（10片×50）[SP] 250毫克 100片（10片×10），500片（10片×50）[SP] 生产商： 大冢制药有限公司 L-Cartin FF tablets（Levocarnitine）エルカルチンFF錠 Brand name : L-CARTIN FF Tablets100mg and 250mg 　Active ingredient: Levocarnitine 　Dosage form: white tablet, diameter: 11.2 mm, thickness: 5.2 mm 　Print on wrapping: Front: OG60, エルカルチンFF錠100mg 250mg, Otsuka; Back: L-Cartin FF tab100mg and 250mg, エルカルチンFF錠100mg 250mg Effects of this medicine This medicine activates mitochondrial function by improving carnitine deficiency and improves symptoms such as convulsive attack and hypotonia. It is usually used to improve carnitine deficiency. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have a renal disorder. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is<<to be written by a healthcare professional>> •For adults: In general, take 1.5 to 3g of the active ingredient daily in 3 divided doses. The dosage may be adjusted according to your condition. For children: In general, take 25 to 100 mg of the active ingredient per kilogram of the body weight daily in 3 divided doses. The dosage may be adjusted according to your condition. This medicine contains 250 mg of the active ingredient in each tablet. Strictly follow the instructions of your doctor and pharmacist. •If you miss a dose, take the dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine • Possible adverse reactions to this medicine The most commonly reported adverse reactions include loss of appetite, diarrhea, loose stool, enlarged feeling of abdomen, facial edema, hematuria and anemia. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. No pertinent entries. The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of reach of children. Store away from direct sunlight, heat and moisture. •As this medicine is highly hygroscopic, the tablets should not be removed from the package sheet until immediately before use. •Discard the remainder. Do not store them. Internal Published: 11/2014 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. http://www.info.pmda.go.jp/go/pack/3999033F1026_1_02/