英文药名: Dexferrum Injection(Iron Dextran Complex)

中文药名: 右旋糖酐铁注射液
药品简介

通用名: 右旋糖酐铁注射液
英文名: IRON DEXTRAN INJECTION
药品类别: 抗贫血药
性状: 本品为深褐色的胶体溶液。

药理毒理
抗贫血药。铁为血红蛋白及肌红蛋白的主要组成成份。血红蛋白为红细胞中主要携氧者。肌红蛋白系肌肉细胞贮存氧的部位，以助肌肉运动时供氧需要。与三羧循环有关的大多数酶均含铁，或仅在铁存在时才能发挥作用。所以对缺铁患者积极补充铁剂后，除血红蛋白合成加速外，与组织缺铁和含铁酶活性降低的有关症状如生长迟缓、行动异常、体力不足、粘膜组织变化以及皮肤指甲病变也均能逐渐得以纠正。

药代动力学
本品由于分子较大，须由淋巴管吸收再转入血液，所以注射后血浓度提高较慢，约24～48小时血药浓度达高峰。铁吸收后与转铁蛋白结合在血中循环，以供造红细胞之用，也可以铁蛋白或含铁血黄素形式累积在肝、脾、骨髓及其他网状内皮组织。铁在人体中每日排泄极微量，见于尿、粪、汗液、脱落的肠粘膜细胞及酶内，丧失总量为0.5～1.0mg。

适应症
用于防治多种原因引起的缺铁性贫血，如慢性失血、营养不良或铁吸收障碍，以及儿童、孕妇需铁量增加而食物供给不足等。

用法用量
深部肌内注射 一次50～100mg（Fe） 1～3日1次。 小儿体重超过6kg者 一次25mg（Fe） 1日1次。 小儿体重6kg以下者 一次12.5mg（Fe） 1日1次。

不良反应
本品注射后，可产生局部疼痛及色素沉着。

禁忌症
(1)对铁剂过敏者。
(2)非缺铁性贫血。
(3)肝肾功能严重损害者。
(4)胃、十二指肠溃疡患者。
(5)溃疡性结肠炎患者。
(6)血色素沉着、含铁血黄素沉着症患者。

注意事项
1．适于不能耐受口服铁剂的缺铁性贫血患者，或需迅速纠正缺铁患者。
2．注射本品后血红蛋白未见逐步升高者应即停药。
3．严重肝、肾功能不全者禁用。

孕妇及哺乳期妇女用药
尚不明确。

规格：50mg/ml 10支 x 2ml  

Iron Dextran Solution for injection

What is this medicine?

IRON DEXTRAN (AHY ern  DEX tran) is an iron complex. Iron is used to make healthy red blood cells, which carry oxygen and nutrients through the body. This medicine is used to treat people who cannot take iron by mouth and have low levels of iron in the blood.
 
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
•anemia not caused by low iron levels
•heart disease
•high levels of iron in the blood
•kidney disease
•liver disease
•an unusual or allergic reaction to iron, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I use this medicine?

This medicine is for injection into a vein or a muscle. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 4 months old for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply as lindane is applied as a single dose. Do not repeat the treatment.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
•deferoxamine
•dimercaprol
•other iron products

This medicine may also interact with the following medications:
•chloramphenicol
•deferasirox

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional regularly. Tell your doctor if your symptoms do not start to get better or if they get worse. You may need blood work done while you are taking this medicine.

You may need to follow a special diet. Talk to your doctor. Foods that contain iron include: whole grains/cereals, dried fruits, beans, or peas, leafy green vegetables, and organ meats (liver, kidney).

Long-term use of this medicine may increase your risk of some cancers. Talk to your doctor about how to limit your risk.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•blue lips, nails, or skin
•breathing problems
•changes in blood pressure
•chest pain
•confusion
•fast, irregular heartbeat
•feeling faint or lightheaded, falls
•fever or chills
•flushing, sweating, or hot feelings
•joint or muscle aches or pains
•pain, tingling, numbness in the hands or feet
•seizures
•unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•change in taste (metallic taste)
•diarrhea
•headache
•irritation at site where injected
•nausea, vomiting
•stomach upset
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.