阿格列汀(吡格列酮苯酸酯,ALOGLIPTIN BENZOATE) 日本武田（Takeda）制药于2010年4月16日宣布该公司研发的治疗2型糖尿病的新药NESINA（通用名：Alogliptin Benzoate，吡格列酮苯酸酯）获得日本厚生劳动省（MHLW）的上市批准，同意将该药用于对血糖控制方法不当的患者，这些患者仅采取运动和食疗方案治疗。 ネシーナ錠25mg／ネシーナ錠12.5mg／ネシーナ錠6.25mg 治疗类别名称 选择性DPP-4抑制剂 -2型糖尿病的治疗剂 - 中文：吡格列酮苯酸酯 适合病症：2型糖尿病 生产厂家：武田制药 商標名 NESINA Tablets 一般名 アログリプチン安息香酸塩（Alogliptin Benzoate）〔JAN〕 化学名 2-（｛6-［（3R）-3-Aminopiperidin-1-yl］-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1（2H）-yl｝methyl）benzonitrile monobenzoate 分子式 C18H21N5O2・C7H6O2 分子量 461.51 化学構造式 融点 182.5℃ 性状 苯甲酸阿格列汀是白色结晶粉末，以黄色。二甲基亚砜微溶于德，微溶于水或甲醇，乙腈或乙醇（99.5）微溶。 包装规格 25mg ：100錠（10錠×10）、500錠（バラ、10錠×50）、700錠（14錠×50） 12.5mg：100錠（10錠×10）、500錠（バラ、10錠×50）、700錠（14錠×50） 6.25mg ： 100錠（10錠×10）、 140錠（14錠×10）、500錠（バラ、10錠×50） 製造販売元 武田薬品工業株式会社 完整处方附件：http://www.info.pmda.go.jp/go/pack/3969012F1025_1_14/ NESINA Tablets 12.5mg（ネシーナ錠12.5mg）  Brand name : NESINA Tablets 12.5mg 　Active ingredient: Alogliptin benzoate 　Dosage form: light yellow oval tablets, major axis 10.1 mm, minor axis 5.1 mm, thickness about 3.4 mm 　Print on wrapping: (Face) ネシーナ　12.5mg　386, (Back) ネシーナ　12.5 NESINA Tablets 25mg（ネシーナ錠25mg）  Brand name : NESINA Tablets 25mg 　Active ingredient: Alogliptin benzoate 　Dosage form: yellow oval tablets, major axis 10.1 mm, minor axis 5.1 mm, thickness about 3.4 mm 　Print on wrapping: (Face) ネシーナ　25mg　387, (Back) ネシーナ　25 NESINA Tablets 6.25mg（ネシーナ錠6.25mg）  Brand name : NESINA Tablets 6.25mg 　Active ingredient: Alogliptin benzoate 　Dosage form: light red oval tablets, major axis 10.1 mm, minor axis 5.1 mm, thickness about 3.4 mm 　Print on wrapping: (Face) ネシーナ　6.25mg　385, (Back) ネシーナ　6.25 Effects of this medicine This medicine inhibits the enzyme (DPP-4) which catalyzes decomposition of incretin, a hormone acting to maintain constant blood glucose level. It stimulates insulin secretion when blood glucose level is elevated and suppresses glucagon secretion to improve blood glucose control. Usually, used for treatment of type II diabetes mellitus. Before using this medicine, be sure to tell your doctor and pharmacist •If you ever experienced any allergic reaction (itch, rash etc.) to any medicine. If you have severe ketosis, diabetic coma or precoma, insulin-dependent diabetes mellitus, or severe infection; are in a pre- or post-operative state; have a serious injury, renal disorder, heart failure, pituitary abnormality, adrenal disorder, or inadequate food intake; or are debilitated, doing strenuous physical exercises, or a heavy drinker. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •General dosage regimen: for adults, take 2 tablets (25 mg of alogliptin) at a time, once a day. The dosage is to be reduced according to degree of existing renal function in patients with moderate or severer renal dysfunction. Strictly follow the instructions of your doctor/pharmacist. •If you missed a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. DO NOT take double doses to make up for the missed dose. •If you took too much of the medicine (more than ordered), check with your doctor/pharmacist. •Do not stop taking the medicine without the instructions of your doctor. Precautions while taking this medicine •Strictly adhere to dietary instructions given and to kinesitherapy prescribed. •Much caution should be exercised as hypoglycemia may occur. •When hypoglycemia symptoms occur, take an adequate amount of sugar (e.g., sugar, glucose, soft drinks). If you are taking the medicine concomitantly with an α-glucosidase inhibitor (drugs which delay absorption of sugar such as voglibose and acarbose), ingest glucose in case of any hypoglycemic symptoms. Possible adverse reactions to this medicine Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: rash, enlarged feeling of abdomen, abdominal pain, gastroenteritis, constipation, headache, dizziness, numbness of hands/feet, malaise, nasopharyngitis, swelling, palpitation, arthralgia, muscle pain, etc. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •cold sweat, hungry feeling, tremor in hands/feet [hypoglycemia] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from direct sunlight, heat and humidity. •Discard the remainder. Do not store them.