英文商品名： Sucraid R

中文商品名： 酵母轉化酶
 
主成分： sacrosidase 。

劑型：
口服溶液， 8500IU/ml, 118m l/bot 之 sacrosidase 。
 
適應症：
先天性蔗糖酶-異麥芽糖酶缺乏症 (congenital sucrase-isomaltase deficiency) 。
 
藥理機轉：
Sacrosidase 主要是由啤酒酵母菌 Saccharomyces cerevisiae 中萃取出之轉化酵素，利用 sacrosidase 可將蔗糖分解以提供身體所需的養分。
 
藥動學：
1. Sacrosidase 主要於腸胃道分解成 peptides 及胺基酸，再進一步吸收。
2. 於服用 sacrosidase 時，可併服含蛋白質的食物，以減少胃中之酸度增加及避免胃蛋白酵素將 sacrosidase 分解。
3. 哺乳：安全。
 
禁忌：
對於肝油、酵母菌或其相關產品易過敏者，須小心使用。
 
副作用：
1. 中樞系統方面：失眠、頭痛。
2. 腸胃道方面：腹痛、噁心、嘔吐、腹瀉、便秘、脫水。
 
懷孕分級： Ｃ
 
交互作用：
果汁：由於果汁的酸性會減少 Sacrosidase 的活性，故須避免使用果汁稀釋，而改以冷水、牛奶或嬰兒食品來稀釋。
 
注意事項：
1. 於初次服用時，為避免病患發生嚴重之過敏反應，建議病患於醫療院所內服用初劑量。
2. 病患於日常飲食須限制澱粉的攝取。
3. 糖尿病之病患於服用 sacrosidase 時須特別注意。
4. 於服用 sacrosidase 時，可將 sacrosidase 加於冷水或牛奶中，但避免將該藥加熱或熱飲中，以避免高溫的破壞。
5. 病患於平常忘記服藥時，不須補服該劑量，僅於下次用餐時再服用 sacrosidase 即可。
 
用法用量：
1. 成人：體重超過15公斤 者，於每次用餐或點心時，服用17000IU 的 sacrosidase (相當於2毫克及 44 滴之溶液 ) ，將該劑量於用餐前及用餐後服用完畢即可。
2. 小孩：體重低於15公斤 者，於每次用餐或點心時，服用 8500 IU的 sacrosidase(相當於1毫克及 22 滴之溶液 ) ，體重超過15公斤者，於每次用餐或點心時，服用17000IU的sacrosidase (相當於 2 毫克及 44 滴之溶液 ) ，將該劑量於用餐前及用餐後服用完畢即可。
 
保存：
由於 sacrosidase 開封後易滋生細菌，故建議 sacrosidase於開封後須於 2 ℃ 至8 ℃內避光保存，約可保存四週，另外若置於 4°C內可以保存6個月。
 
廠商： 
  •  藥　商： 科懋生物科技股份有限公司

Sucraid (Sacrosidase Oral Solution)
Sucraid® (sacrosidase) Oral Solution is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of congenital sucrase-isomaltase deficiency (CSID).
IMPORTANT SAFETY INFORMATION FOR SUCRAID® (SACROSIDASE) ORAL SOLUTION
•Sucraid® may cause a serious allergic reaction. If you notice any swelling or have difficulty breathing get emergency help right away.
•Sucraid® does not break down some sugars that come from the digestion of starch. You may need to restrict the amount of starch in your diet. Your doctor will tell you if you should restrict starch in your diet.
•Tell your doctor if you are allergic to, have ever had a reaction to, or have even had difficulty taking yeast, yeast products, papain or glycerin (glycerol).
•Tell your doctor if you have diabetes as your blood glucose levels may change if you begin taking Sucraid®. Your doctor will tell you if your diet or diabetes medicines need to be changed.
•Some patients may have worse abdominal pain, vomiting, nausea or diarrhea. Constipation, difficulty sleeping, headache, nervousness and dehydration have also occurred. Check with your doctor if you notice these or other side effects.
•Sucraid® has not been tested to see if it works in patients with secondary (acquired) sucrase deficiency.
•NEVER HEAT SUCRAID® OR PUT IT IN WARM OR HOT BEVERAGES OR INFANT FORMULA. Do not mix Sucraid® with fruit juice or take it with fruit juice. Take Sucraid® as prescribed by your doctor. Normally half of the dose of Sucraid® is taken before a meal or snack and the other half is taken during the meal or snack.
•Sucraid® should be refrigerated at 36°F-46°F (2°C-8°C) and should be protected from heat and light.