英文药名：DIQUAS（Diquafosol Sodium ophthalmic solution 3%） 中文药名：地夸磷索四钠滴眼液3% 生产厂家：参天制药 ジクアス点眼液3％ 长效滴眼药：Diquas（Diquafosol Sodium）是全球获准上市的首个P2Y2受体激动剂滴眼液，耐受性好，可长期使用. 批准上市日期：2011年11月 商標名 DIQUAS ophthalmic solution 3% 一般名 ジクアホソルナトリウム（Diquafosol Sodium） 化学名 Tetrasodium P 1, P 4-bis（5'-uridyl）tetraphosphate 構造式 分子式 C18H22N4Na4O23P4 分子量 878.23 性状 该产品是白色结晶粉末。它易溶于水，易溶于甲酰胺，不溶于甲醇，难溶于乙醇。 药理学 作用机序 1. 通过作用于P2Y2受体的杯状细胞的膜和结膜上皮细胞，从而提高细胞内钙离子浓度，Diquafosol钠促进粘蛋白和水的分泌。 2.泪液分泌促进作用，包括粘蛋白 (1)在（大鼠和兔）正常动物，并从结膜细胞促进黏液分泌和眼泪Diquafosol钠单一灌输的分泌。 (2) 在大鼠干眼模型，并通过Diquafosol钠单次滴眼促进泪液分泌。另外，粘蛋白在结膜组织的量增加了反复滴眼。 3.改善角膜上皮障碍 一天Diquafosol钠，在4周的重复灌注以浓度依赖性方式提高6倍，在大鼠干眼症模型角膜上皮病症表明在1％或更高的最大效果。另外，在1％的2周重复滴注，显示最大的改善，每天在6次以上. 适应症: 本品用于干眼症 剂量与用法 每天6次/滴，每次一滴 包装规格 塑料吸管 ５ｍＬ/支×10管/盒 ５ｍＬ/支×50管/盒 制造厂商 参天制药有限公司 完整处方资料附件：http://www.info.pmda.go.jp/go/pack/1319758Q1021_1_08/ 产品特点及上市 3%地夸磷索四钠(Diquafosol sodium)滴眼液是参天和Inspire两制药公司联合开发的产品(商品名：Diquas ジクアス点眼液3％)，用于治疗干眼病。2010年在日本上市。 Diquas是全球获准上市的首个P2Y2受体激动剂滴眼液，以新作用机制治疗干眼病：通过促进水和黏蛋白分泌改善干眼病症状，使泪膜更接近正常状态。在日本的临床研究中，未发现严重的眼部和全身性不良反映。Diquas用药的耐受性好，故可用于长期治疗干眼病症状。 DIQUAS ophthalmic solution 3%(ジクアス点眼液3％) Brand name : DIQUAS ophthalmic solution 3% 　Active ingredient: Diquafosol sodium 　Dosage form: colorless, limpid ophthalmic solution, 5mL, (bottle) colorless, limpid, (cap) clear bright blue 　Printings on wrapping:  Effects of this medicine This medicine stimulates the secretion of mucin and water in the ingredients of tears. It helps improve tear conditions, and cures corneal and conjunctival injuries. It is usually used to cure dry eye. Before using this medicine, tell your doctor/pharmacist If you ever experienced any allergic reaction (itch, rash etc.) to any medicine. If you wear contact lenses. If you are pregnant or breastfeeding. If you are using any other prescription or nonprescription (OTC) medicine. (It is important to reduce the risk of drug interactions.) Dosage regimen (proper use of this medicine) Your dosage regimen is:(order of your doctor) General dosage regimen: Apply 1 drop at a time, 6 times a day. Strictly follow the instructions of your doctor/pharmacist. Before using, wash your hands thoroughly with soap and running water. Pull down your lower eyelid so that the dropper tip does not touch eye or eyelashes. After dropping the solution into your eye, do not blink, and keep your eyes closed for a while. Wipe off any excess liquid with a clean gauze or tissue. If you need to use other eye drops at the same time, wait more than 5 minutes. Missed dose: Apply as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular applying schedule. DO NOT use double doses to make up for the missed dose. Overdose: If you used too much of the medicine (more than ordered), check with your doctor/pharmacist. Others: Do not stop using the medicine without the instructions of your doctor. Precautions while using this medicine Do not use the medicine while you wear liquid-containing contact lenses. Side effects of this medicine Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: stinging eyes, eye mucus, bloodshot eyes, eye pain, itchy eyes, foreign body sensation in eyes, eye discomfort, etc.In rare cases, symptoms described below may be the sign of side effects indicated in brackets [ ]. If they occur, stop taking your medicine and check with your doctor immediately.No pertinent entries.Other side effects not listed here may occur. Check with your doctor/pharmacist if you have any worrisome symptom. Storage and other information Keep out the reach of children. Store away from heat and direct sunlight. Discard the remainder. Do not store them. Manufacturer's name : Santen Pharmaceutical Co.,Ltd. 621985701