| sutent is a medicine that treats cancer. It comes in 12.5-mg, 25-mg, and 50-mg capsules. You take SUTENT once per day by mouth. Do not open the capsules.
索坦是一种抗癌药物。它是一种胶囊剂，有12.5毫克、25毫克和50毫克三种不同的规格。
SUTENT has been approved by the FDA to treat patients with gastrointestinal stromal tumor (GIST). SUTENT is used when the medicine Gleevec® (imatinib mesylate) does not stop the cancer from growing or when you cannot take Gleevec. 索坦已经被FDA批准用于治疗胃肠道间质瘤（GIST）患者，适用于使用格列（甲磺酸伊马替尼）无效、进展或不能使用格列卫的患者。
SUTENT is available by prescription only. Your doctor has prescribed SUTENT because he or she believes it is the most appropriate treatment for you. SUTENT may not be appropriate for all GIST patients and has not been studied in children. For many patients, SUTENT may slow or stop the growth of cancer and may help to shrink tumors. SUTENT may not work the same in every person. 索坦只能通过医生处方获得。医生给您开索坦是因为他/她认为这是对您最好的治疗方法。索坦并不适合所有的胃肠道间质瘤的患者，且并未对儿童患者进行研究。对很多患者，索坦可以延缓或阻止肿瘤的进展，并帮助消退肿瘤。但索坦对每个人的作用不一样。
 索坦的作用机理？
SUTENT may slow or stop some cancers, such as GIST. It works by blocking 2 basic processes that cause tumors to grow and spread. These processes are called proliferation and angiogenesis.
索坦可以延缓或阻止某些肿瘤的进展，如胃肠道间质瘤。它通过阻滞被称为肿瘤繁殖和血管生成的两个过程（引起肿瘤的生长和扩散）来发挥作用。
 proliferation繁殖 This is when a cell divides, creating 2 cells where there used to be only 1. Like the other cells in your body, cancer cells divide. The difference is that cancer cells divide more times than they should, forming a tumor. SUTENT may help slow down this process. 这个过程指的是一个细胞一分为二，变成两个细胞。像正常细胞一样，癌细胞也是通过这种分裂的方式进行繁殖。它们的区别在于癌细胞比普通细胞分裂速度要快得多，从而形成肿瘤。索坦可以帮助延缓这个过程。
 Angiogenesis 血管生成 This is when new blood vessels form. These new blood vessels give tumors the nutrients and oxygen they need to grow. SUTENT may help stop this process.
这个过程指的是新血管的形成。新形成的血管提供肿瘤生长所需的营养和氧分。索坦可以阻止这个过程。
SUTENT may help stop proliferation and angiogenesis by blocking the signals that cause them. Without these 2 processes, tumors cannot grow. 索坦可以通过阻止细胞信号传导来阻止肿瘤细胞的繁殖和肿瘤血管的形成。没有这两个过程，肿瘤就不能生长。
 怎样和医生沟通？需要告诉医生什么？
Before starting treatment, tell your doctor if you are pregnant, could be pregnant, or plan to get pregnant. SUTENT may harm an unborn baby. 开始治疗前，如果您已经怀孕、可能怀孕或计划怀孕，请告诉医生。索坦可以对胎儿造成伤害。
Tell your doctor if you are breastfeeding. Do not breastfeed while you are being treated with SUTENT. 如果您正在母乳喂养，请告诉医生。使用索坦进行治疗期间务必不要进行母乳喂养。
Tell your doctor about all of your medical conditions, especially if you have any of the following:
告诉您的医生关于您的疾病状况的所有信息，尤其当您有以下任何情况时：心脏问题、高血压、肾功能不全（除了癌症）、肝脏问题、任何出血问题和癫痫。
Tell your doctor about all of the medicines you take, including prescription drugs, over-the-counter drugs, vitamins, and herbal products. Some medicines can react with SUTENT and cause serious side effects, including St. John's Wort. Do not take St. John's Wort while taking SUTENT.
告诉您的医生您的正在进行的用药情况，包括处方药、OTC、维他命和草药。一些药品可以和索坦相互作用而引起副作用，包括贯叶连翘提取物。
Other medicines can react with SUTENT. These include: · Dexamethasone (a steroid)
· Medicine for:
· Tuberculosis (TB)
· Infections (antibiotics)
· Depression
· Seizures (epilepsy)
· Fungal infections (antifungals)
· HIV (AIDS)
其他能与索坦相互作用的药品包括:地塞米松、治疗结核的药物、抗生素、抗抑郁剂、抗癫痫、抗真菌类药物和抗艾滋病药物。
Keep a list of your medicines and show it to your doctor or pharmacist. Also, talk with your doctor before starting any new medicines.
把您所用的药品做一个清单交给您的医生或药师。同时，在开始服用新药前先咨询下医生。
 怎样服用索坦？
索坦是一种胶囊制剂，有12.5毫克、25毫克和50毫克三种不同的规格。患者需按疗程服用直到医生通知停药：口服，每天一次，一个疗程6周，头四周每天一次顿服50毫克，然后停药并观察两周。
 Important things to remember 用药须知
Follow your doctor's or nurse's instructions on how and when to take SUTENT
怎样服用和何时服用索坦请遵照医生和护士的指导。
Make sure to tell your doctor or nurse if you are taking any other medicines, vitamins, or herbal products
如果您正在服用维他命、草药或其他药品，请务必告诉您的医生。
This includes any supplements or over-the-counter products
Take SUTENT exactly the way your doctor tells you to. Do not open the capsules
Try to take SUTENT at about the same time each day
SUTENT can be taken with or without food
Do not drink grapefruit juice or eat grapefruit because this can change the amount of SUTENT in your body
Do not take St. John's Wort while taking SUTENT
If you miss a dose, take it as soon as you remember unless it is close to the time for your next dose. Do not take more than 1 dose of SUTENT at a time, and tell your doctor or nurse if you miss a dose
Call your doctor right away if you take too much SUTENT (more than 1 dose of SUTENT at a time)
这些产品包括，任何补品、OTC产品。
请按照医生告诉您的方法正确服用，一定不要嚼开胶囊。
每天尽量在固定时间服药。
可以和或不和食物一起使用。
一定不要吃葡萄或饮用葡萄汁，因为葡萄所含的物质可以改变您体内的索坦的浓度。
如果忘记服药，当您记起时请立即服用，除非已经到货就要到下一次服药的时间了。一次不能服用过量，忘记服药请通知您的医生和护士。
服用过量请立即通知您的医生（超过一次该服用的剂量） |
