英文药名: Bystolic(Nebivolol Tablets)

中文药名: 奈必洛尔片

药品名称

奈比洛尔为β-阻段剂系列高血压治疗药物的新成员。12月17日，FDA宣布批准抗高血压新药奈比洛尔(nebivolol，Bystolic)上市。奈比洛尔为β-阻段剂系列高血压治疗药物的新成员。在美国，成年人高血压发病率约为1/3。高血压平时没有特别症状，但可导致中风、心衰、心脏病发作、肾衰竭甚至死亡的风险，因此常被称作隐行杀手。奈比洛尔为患者控制血压提供了新选择。
适应症

具有血管扩张活性的选择性β1肾上腺素受体拮抗剂，无内源性产感神经活性。用于轻至中度高血压病人的治疗，亦可用于心绞痛和充血性心力衰竭的治疗。
规格

片剂，2.5mg; 5mg/片。
用法用量

一日一次，一次一片，肝肾功能不全及老年人可适当减量。
任何疑问，请遵医嘱！
不良反应

本品不良反应较少，最常见的有头痛、眩晕、乏力、感觉异常、便秘、腹泻等。这些不良反应通常是一过性的，很少因此而停药。本品不引起体位性低血压，很少诱发心衰或引起严重缓慢性心律失常。
包装规格：
·5mg *84 片
·2.5mg *100 片
·5mg *100 片

BYSTOLIC

Generic Name for BYSTOLIC

Nebivolol (as HCl) 2.5mg, 5mg, 10mg; tabs.

Legal Classification:

Rx

Pharmacological Class for BYSTOLIC

Cardioselective β-blocker.

Manufacturer of BYSTOLIC

Forest Laboratories

Indications for BYSTOLIC

Hypertension.

Adult dose for BYSTOLIC

≥18yrs: initially 5mg once daily. Individualize; may increase at 2-week intervals; max 40mg/day. Severe renal or moderate hepatic impairment: initially 2.5mg once daily.

Children's dosing for BYSTOLIC

<18yrs: not recommended.

Contraindications for BYSTOLIC

Severe hepatic impairment (Child-Pugh >B). Severe bradycardia. 2^nd- or 3^rd-degree AV block. Cardiogenic shock. Overt heart failure. Sick sinus syndrome (unless paced).

Warnings/Precautions for BYSTOLIC

CHF. Angina. Recent MI. Bronchospastic disease. Diabetes. Hyperthyroidism. Severe renal impairment. Moderate hepatic impairment. Avoid abrupt cessation (taper over 1–2 weeks). Surgery. Peripheral vascular disease. Pheochromocytoma. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions for BYSTOLIC

Caution with phenylalkylamine and benzothiazepine calcium channel blockers (eg, verapamil, diltiazem), antiarrhythmics (eg disopyramide), digoxin, reserpine, guanethidine; monitor. May be potentiated by CYP2D6 inhibitors (eg, quinidine, propafenone, paroxetine, fluoxetine); may need to reduce dose. If on both nebivolol and clonidine, discontinue nebivolol before tapering clonidine. May block epinephrine.

Adverse Reactions for BYSTOLIC

Headache, fatigue, dizziness, GI upset.

How is BYSTOLIC supplied?

Tabs—30, 100

FDA未批准Bystolic治疗慢性心衰竭

Forest Labs宣布，美国FDA并未批准Bystolic(R) (nebivolol)治疗慢性心衰竭(CHF)。
奈比洛尔为β-阻段剂系列高血压治疗药物的新成员。12月17日，FDA宣布批准抗高血压新药奈比洛尔(nebivolol，Bystolic)上市。奈比洛尔为β-阻段剂系列高血压治疗药物的新成员。 在美国，成年人高血压发病率约为1/3。高血压平时没有特别症状，但可导致中风、心衰、心脏病发作、肾衰竭甚至死亡的风险，因此常被称作隐行杀手。奈比洛尔为患者控制血压提供了新选择。

3项持续3个月以上的随机双盲多中心安慰剂对照的临床研究评价了奈比洛尔的疗效和安全性。 第4项安慰剂对照研究中，服用其它2种降压药物后降压效果不充分的患者，再接受本品治疗，达到了良好的效果。4项临床研究中总共超过2000例患者服用奈比洛尔，其药效与同类β-阻段剂药物的药效相当。 临床研究中，奈比洛尔最常见不良反应为头疼、疲劳、头晕和腹泻。

Bystolic由北卡罗莱纳州的Mylan Bertek制药公司开发，纽约Forest Laboratories公司负责奈比洛尔的销售

Generic Bystolic Description
Bystolic (Nebivolol) falls in the class of medicines known as beta blockers. It is used alone or in combination with other drugs in the treatment of hypertension. Nebivolol is available in the form of tablets. You should buy Bystolic online or from any local drugstore only after confirming all positive and negative effects of it with your health care provider.
How To Use Bystolic
This is an orally administered medication. The dosage is decided considering your medical condition and the rate of your response to the treatment. Usually, Bystolic is given once in a day. You can take it before or after meals. It is advised to take it at the same time each day. You should not make any changes in your dosage on your own. Do not discontinue taking this medication without consulting your health care provider. Discontinuing suddenly may lead to serious consequences including heart attack. If at all you need to stop taking this medication, the dosage is gradually reduced and so it must be done with your heath care provider’s advice.
Bystolic Side Effects
Like many other medications, Bystolic also has some side effects. Some of them can be listed as below:

Headache

Tiredness

Disturbed sleep

Nausea

There could be some more side effects of this medication than listed above. If you encounter any such side effects, contact your health care provider without delay.
Bystolic Interactions
Before you purchase Bystolic, you must inform your health care provider if you are using any other medicines or herbal products. There are some medications that may interact with Nebivolol; few of them are as follows:

Digoxin

Catapres

Cardizem

Covera

Verelan

Plendil

Pacerone

Norpace

Tambocor

Rythmol

Pronestyl

Prozac

Coreg

Tenormin

Corgard

Betapace

Normodyne

Paxil

Isoptin

This list does not comprise of all likely medicines that may interact with Bystolic. If you wish to know more about Bystolic interactions you can talk to your health care provider or to the local pharmacist.
Bystolic Overdose
If you notice that you have taken an extra dose or if you find any overdose symptoms like: dizziness, difficulty in breathing, vomiting, etc., rush to seek medical attention immediately. You can also call 1-800-222-1222 and report to the local poison control center or 911 for the local emergency services.
Bystolic Notes

You should not share your medication with anyone else.

Take this medication regularly without fail.

If you need to undergo any type of surgery inform your surgeon that you are currently taking this medication.

Do not miss any appointments with your health care provider as your blood pressure needs to be checked often.

Bystolic is not a complete treatment; you also need to follow your diet and exercise program.

There are no visible symptoms of high blood pressure; hence keep using this medication even if you feel perfectly fine.

You may need to perform some lab tests to monitor your progress and to check out any side effects.

While taking this medication, avoid driving or using any machinery that requires alertness.
For the rest of your life, you will require to take blood pressure medication.
Bystolic Missed Dose
If you happen to miss your dose, take it at the earliest once you remember it. However, if your next dose timing is nearing then skip the missed dose and take only the regular scheduled dose. In any case, do not try to take double doses or increased doses.
Bystolic Uses
Bystolic is used to treat hypertension (high blood pressure). Beta-blockers help in easing the blood flow through the body and result in reducing the pressure on the heart. Thus it helps in preventing heart attacks, strokes and also kidney problems.
Bystolic Other Uses
Bystolic may also be used in the treatment of coronary artery disease or angina. This medication can be used for some other purposes as well. You can discuss with the local pharmacist or your doctor about the other uses whenever you buy Bystolic from your local pharmacy.
Bystolic Storage
You should store Bystolic at room temperature and away from direct sunlight, heat and moisture. Make sure to maintain it away from pets and children. Do not keep it in the bathroom or kitchen. You should not keep any outdated and unwanted medicines at home, discard them off without delay. If you want to know the proper way of disposing this medication; you can ask about the same to your health care provider or to the pharmacist.
Bystolic Precautions
It is important to let your health care provider know if you are pregnant or planning to become pregnant as Bystolic may have some adverse effects on an unborn baby.
While taking this medication if you become pregnant; inform your health care provider right away.