|
英文药名: Benicar HCT (Olmesartan Medoxomil/Hydrochlorothiazide Tablets)
中文药名: 奥美沙坦酯氢氯噻嗪片
生产厂家: Sankyo Pharma
药品名称
英文药名: Benicar HCT (Olmesartan Medoxomil/Hydrochlorothiazide Tablets)
中文药名: 奥美沙坦酯氢氯噻嗪片
药品介绍
另有研究显示奥美沙坦酯与利尿剂氢氯噻嗪联合应用具有协同作用。美国FDA现已批准日本三共制药公司的奥美沙坦酯(Olmesartan Medoxomil)/氢氯噻嗪(HCTZ)复方制剂(商品名：Benicar HCT)，作为治疗高血压的二线药物。有3种剂量，规格为：奥美沙坦/HCTZ 20 mg/12.5 mg, 20mg/25mg, 40mg/25mg, 40 mg/12.5 mg, 80 mg/12.5 mg。
本品是结合血管紧张素Ⅱ受体拮抗剂奥美沙坦和利尿药氢氯噻嗪，较安慰剂平均降低收缩压和舒张压分别为3.19KPa和1.9KPa。临床研究显示，奥美沙坦与氢氯噻嗪合用，显著降低高血压患者的血压。
BENICAR and BENICAR HCT: Multiple Dosing Options With Convenient Once-Daily Dosing
BENICAR dosing options
*A BENICAR 5-mg tablet is available for patients requiring a lower dose.
20 mg once daily — usual recommended starting dose
40 mg once daily — for patients requiring further reduction in blood pressure after 2 weeks of therapy
BENICAR HCT dosing options
20 mg olmesartan medoxomil and 12.5 mg hydrochlorothiazide (HCTZ)
40 mg olmesartan medoxomil and 12.5 mg HCTZ
40 mg olmesartan medoxomil and 25 mg HCTZ
BENICAR may be administered with or without food.
No initial dosage adjustment is recommended for elderly patients, for patients with moderate-to-marked renal impairment (creatinine clearance <40 mL/min), or for patients with moderate-to-marked hepatic dysfunction.
A patient whose blood pressure is inadequately controlled by BENICAR or hydrochlorothiazide alone may be switched to once-daily BENICAR HCT. Dosing should be individualized. Depending on the blood pressure response, the dose may be titrated at intervals of 2–4 weeks. BENICAR HCT is not indicated for initial therapy.
BENICAR HCT may be substituted for its titrated components.
In patients with renal impairment, the usual regimens of therapy with BENICAR HCT may be followed, provided the patient’s creatinine clearance is >30 mL/min. In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so BENICAR HCT is not recommended. No dosage adjustment is necessary with hepatic impairment.
In patients with possible depletion of intravascular volume (eg, patients treated with diuretics, particulary those with impaired renal function), BENICAR should be initiated under close medical supervision and consideration should be given to use of a lower starting dose.
BENICAR HCT is contraindicated in patients who are hypersensitive to any component of this product.
Because of the hydrochlorothiazide component, BENICAR HCT is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs.
--------------------------------------------------------------------
 | Benicar and Benicar HCT are prescription medicines used to lower high blood pressure (hypertension). They may be used alone or with other medicines used to treat high blood pressure. Benicar HCT is not for use as the first medicine to treat your high blood pressure.
Important Safety Information
WARNING: DO NOT TAKE BENICAR OR BENICAR HCT DURING PREGNANCY
If you become pregnant, stop taking Benicar or Benicar HCT. Call your doctor right away. Benicar and Benicar HCT can cause injury or death to an unborn baby. If you plan to become pregnant, talk with your doctor about other treatments to lower blood pressure. Please see the WARNING section of the full product information about avoiding use in pregnancy. |
Before taking Benicar or Benicar HCT, tell your doctor if you are pregnant. Also tell your doctor if you are breast-feeding or plan to breast-feed. A medicine in Benicar HCT can pass into your breast milk. This may harm your baby. You and your doctor should decide if you will take Benicar or Benicar HCT or breast-feed. You should not do both.
Do not take Benicar HCT if you:
Have severe kidney disease
Have low or no urine output
Are allergic to other sulfonamide type medicines
Tell your doctor if you are allergic to any of the ingredients in Benicar or Benicar HCT (see the Prescribing Information for a list of the ingredients in Benicar or Benicar HCT). Also, tell your doctor if you have liver or kidney problems or if you have lupus. If you are vomiting, have a lot of diarrhea, or have any other medical conditions, be sure to tell your doctor.
Tell your doctor about all the medicines you take. These medicines may include prescription and nonprescription medicines, vitamins, and herbal supplements. If you are taking Benicar or Benicar HCT, be sure to tell your doctor if you are taking:
Water pills (diuretics)
Other medicines for high blood pressure or a heart problem
Potassium supplements or a salt substitute that contains potassium
Pain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs)
If you are taking Benicar HCT, also tell your doctor if you are taking:
Diabetes medicine, including insulin
Narcotic pain medicine
Sleeping pills and antiseizure medicines called barbiturates Lithium for certain types of depression Steroids
Cholesterol medicines
Some of your other medicines and Benicar or Benicar HCT could affect each other. This may cause serious side effects. Take Benicar or Benicar HCT as prescribed by your doctor. If you choose to stop taking Benicar or Benicar HCT, talk with your doctor first.
Benicar and Benicar HCT may cause serious side effects. These include injury or death to an unborn baby; low blood pressure (hypotension), which may cause you to feel faint or dizzy; and kidney problems, which may get worse in people with kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose of Benicar or Benicar HCT. Tell your doctor if you get swelling in your feet, ankles, or hands, or have unexplained weight gain. These may be signs of kidney problems.
Other serious side effects of Benicar HCT include allergic reactions due to the thiazide diuretic (water pill), and changes in body salts (such as sodium and potassium) and fluids. Tell your doctor if you have these signs and symptoms: dry mouth, thirst, weakness, tiredness or sleepiness, restlessness, confusion, seizures, muscle pains or cramps, muscle tiredness, dizziness or fainting, having little or no urine output, fast heartbeat, or nausea and vomiting.
Hydrochlorothiazide (an ingredient in Benicar HCT) can also cause eye problems, which may lead to vision loss. Symptoms can happen within hours to weeks of starting Benicar HCT. Tell your doctor if you have a decrease in vision or eye pain.
The most common side effect of Benicar and Benicar HCT was dizziness. Other side effects of Benicar HCT included upper respiratory tract infections, more uric acid in the blood, and nausea. Tell your doctor if a side effect bothers you or does not go away.
Tell your doctor if you have side effects. These are not all the possible side effects of Benicar or Benicar HCT. For more information, talk with your doctor or pharmacist. Call your doctor for medical advice about side effects.
You may report side effects by calling 1-877-437-7763 or the FDA at 1-800-FDA-1088.
------------------------------------------------------
包装规格
·20mg/12.5mg*30片
·20mg/25mg *28片（Pfizer 生产）
·40mg/12.5mg *30片
·40mg/25mg *28片（Schering生产）
·20mg/12.5mg *30 片
·40mg/12.5mg *100片 （Merck生产） | 
