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当前位置:药品说明书与价格首页 >> 消化系统药物 >> 胃病 >> 泮托拉唑钠片|PROTONIX(PANTOPRAZOLE SODIUM TABLETS)

泮托拉唑钠片|PROTONIX(PANTOPRAZOLE SODIUM TABLETS)

2014-03-11 23:01:36  作者:新特药房  来源:互联网  浏览次数:166  文字大小:【】【】【
简介:泮托拉唑钠肠溶片在临床中主要用于消化性溃疡等疾病。 【主要成分】泮托拉唑钠。 【适应症】用于十二指肠溃疡、胃溃疡、反流性食管炎、卓艾综合症感染。 【用法用量】口服,每次40mg,每日一次,早晨服用,疗程 ...

泮托拉唑钠肠溶片在临床中主要用于消化性溃疡等疾病。
【主要成分】泮托拉唑钠。
【适应症】用于十二指肠溃疡、胃溃疡、反流性食管炎、卓艾综合症感染。
【用法用量】口服,每次40mg,每日一次,早晨服用,疗程2~4周。
【不良反应】偶见头晕、失眠、嗜睡、恶心、腹泻、便秘、皮疹和肌肉疼痛等症状,大剂量使用时可出现心律不齐,转氨酶升高,肾功能改变,粒细胞降低等。
【禁忌】对本品过敏的患者禁用。
【注意事项】
1、当怀疑胃溃疡时,应首先排除癌症的可能性,因为本品可减轻其症状,从而延误诊断。
2、肝肾功能不全者慎用。因本品经肝脏代谢,肾脏排泄,故肝功能损害患者若使用本品应减量使用,同时监测肝脏酶谱的变化,若测定值升高则应停止用药。肾功能受损的患者对此药代谢的影响不太明显,但也应控制日使用剂量不超过40mg.
3、本品抑制胃酸分泌的作用强,时间长,故应用本品时不宜同时再服用其它抗酸剂或抑酸剂。为防止抑酸过度,在一般消化性溃疡等病时,不建议大剂量长期应用(卓-艾综合征例外)。


PROTONIX TABLETS
Generic Name and Formulations:
Pantoprazole (as sodium) 20mg, 40mg; e-c delayed-release tabs.

Company:
Pfizer Inc.
Indications for PROTONIX TABLETS:
Short-term treatment and maintenance of healing of erosive esophagitis (EE). Pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome).

Adult Dose for PROTONIX TABLETS:
Swallow whole. Do not crush or chew granules. Susp: Take 30mins before a meal. Mix contents of packet in 5mL of apple juice or applesauce (do not mix in water, other liquids or foods); then swallow. May give via NG tube (see literature). Treatment of EE: 40mg once daily for ≤8 weeks; if not healed, may repeat for 8 more weeks. Maintenance of EE healing: 40mg once daily. Pathological hypersecretory conditions: initially 40mg twice daily; max 240mg/day.

Children's Dose for PROTONIX TABLETS:
Swallow whole. Do not crush or chew granules. Susp: Take 30mins before a meal. Mix contents of packet in 5mL of apple juice or applesauce (do not mix in water, other liquids or foods); then swallow. May give via NG tube (see literature). <5yrs: not recommended. Treatment of EE: Give once daily for up to 8 weeks. ≥5yrs: (≥15kg to <40kg): 20mg; (≥40kg): 40mg.

See Also:
PROTONIX for ORAL SUSP

PROTONIX I.V.

Pharmacological Class:
Proton pump inhibitor.

Warnings/Precautions:
Gastric malignancy. Increased risk of osteoporosis-related fractures of the hip, wrist or spine with long-term and multiple daily dose PPI therapy. Monitor magnesium levels with long-term therapy. Reevaluate periodically. IV: consider zinc supplementation in those prone to zinc deficiency. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:
Concomitant atazanavir or nelfinavir: not recommended. May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, iron, ampicillin). Concomitant digoxin or drugs that may cause hypomagnesemia (eg, diuretics); consider monitoring magnesium levels. Monitor warfarin. May give antacids concomitantly. IV: caution with concomitant other EDTA-containing products. May potentiate methotrexate. May cause false (+) urine THC test.

Adverse Reactions:
Headache, GI upset, dizziness, arthralgia, inj site reactions; also children: upper respiratory infection, fever, rash, abdominal pain; rare: cyanocobalamin deficiency, hypomagnesemia (w. prolonged PPI therapy), possible C. difficile associated diarrhea.

Metabolism:
Hepatic (CYP2C19, 3A4). 98% protein bound.

Elimination:
Renal (primarily), fecal.

Generic Availability:
Tabs, IV (YES); oral soln (NO)

How Supplied:
Tabs—90; Susp—30 packets/box; Vials (40mg)—10, 25

责任编辑:admin


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