| 【药物名称】泰索帝 Docetaxel
【药物类别】其他抗肿瘤药 【药物别名】多西他赛 Taxotere 【分子式成分】分子量807.9。 【制剂规格】注射剂：20、80mg 【药理毒理】属于紫杉类化合物抗肿瘤药。 【药动学】按剂量100mg/m2静滴本品约1～2h，体内平均分布容积为113L，t1/2α为4min，t1/2β为36min，t1/2γ约为11.2h。体内清除率约为20L/h.m2，具有高蛋白结合率和低肾排泄率。在肝中代谢，主要经胆道从粪便排出，而经尿排泄仅占所给剂量5%～7%；肝功能异常者使本品在体内清除率减少，但年龄差异对本品在体内的药动学无明显改变。 【适应证】乳腺癌和非小细胞癌。肺癌、卵巢癌有效，对胰腺癌、胃癌、头颈癌等也有效 【不良反应】骨髓抑制。过敏反应。体液潴留。可能发生胃肠道反应如恶心、呕吐或腹泻。脱发。乏力。粘膜炎。关节痛和肌肉痛。低血压。神经毒性和心血管副反应极少发生。 【相互作用】本品和顺铂或长春瑞宾或阿霉素合用，提示有益的结果。与酮康唑合用，可能发生不良相互作用，使用时要格外小心。 【用法用量】推荐剂量为每3周用75 mg/m2，静脉滴注1 hr。 【注意事项】白细胞数目小于1500/m3的病人禁用。孕期、哺乳期妇女及儿童禁用。
Taxotere What is Taxotere? Taxotere is used to treat breast cancer, lung cancer, prostate cancer, stomach cancer, and head/neck cancer. Taxotere may also be used for other purposes not listed in this medication guide. ------------------------------------------------------------- Important information about Taxotere Some people receiving a Taxotere injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, light-headed, warm, or itchy, or if you have chest tightness or trouble breathing during the injection. Taxotere can lower the blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor. Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection, especially fever. There are many other drugs that can interact with Taxotere. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. ------------------------------------------------------------- If you have any of these conditions, you may need a dose adjustment or special tests to safely receive Taxotere. FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use Taxotere without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether Taxotere passes into breast milk or if it could harm a nursing baby. Do not receive Taxotere without telling your doctor if you are breast-feeding a baby. ------------------------------------------------------------- Your doctor may prescribe a steroid medicine for you to take for a few days before your injection. This will help prevent swelling or an allergic reaction to Taxotere. Do not miss any doses of the steroid. Taxotere must be given slowly through an IV and it may take up to an hour to complete your dose. Taxotere can be harmful if it gets on your skin during an IV infusion. If this happens, wash the skin thoroughly with soap and warm water. Taxotere is usually given once every 3 weeks, and you may receive other cancer medicines at the same time. Your doctor will determine a treatment schedule for you based on the type of cancer being treated and other factors. Taxotere can lower the blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled appointments. ------------------------------------------------------------- ------------------------------------------------------------- ------------------------------------------------------------- Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection, especially fever. Avoid allowing this medicine to get on your skin during an IV infusion. If this does happen, wash the skin thoroughly with soap and warm water. ------------------------------------------------------------- Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: Less serious side effects may include: This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088. ------------------------------------------------------------- There are many other drugs that can interact with Taxotere. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. ------------------------------------------------------------- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. 注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
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