部份中文依泽替米贝资料（仅供参考） Vytorin是依泽替米贝和辛伐他汀合剂，属于降胆固醇药物，应用到高胆固醇的个人。 Vytorin是通过减少小肠对胆固醇的吸收从而达到降低胆固醇的作用。 Vytorin用于具有高胆固醇或原发性高胆固醇血症患者。通常当另一种降胆固醇药物，结合低胆固醇的饮食和运动不足以降低胆固醇时使用Vytorin。 Vytorin对胆固醇过高和饮食本身不能充分地降低胆固醇病人的作用很好。 Vytorin降低总胆固醇，低密度脂蛋白（坏）胆固醇和甘油三酯，增加高密度脂蛋白（好的）胆固醇。低密度脂蛋白胆固醇是'坏'胆固醇，可以阻塞血管。高密度脂蛋白胆固醇通常被称为'好'胆固醇，因为它有助于防止坏胆固醇堆积在动脉上并且预防心脏病。Vytorin也可以增加血液中的高密度脂蛋白（好）从而减少对小动脉的硬化，减少了心脏病，中风硬化的风险，以及周边血管疾病。 Vytorin应该根据医生的指导下服用。即使没有立即有所好转，继续按医生的规定服用。对Vytorin的服用剂量不同的病人不同，一般每天一次在睡前服用，与食物同服并饮用一杯水, 或遵医生推荐的口服剂量。 Vytorin由默克公司生产，目前可提供10毫克，20毫克，40毫克和80毫克片剂。 可能的副作用：过敏性反应，呼吸困难，肿胀的嘴唇，尿液减少或铁锈色的尿，视力模糊，腹胀，恶心，肠胃不适，胃灼热，腹痛，便秘或腹泻，咳嗽，疲劳，头痛，失眠等。 Vytorin (Ezetimibe and Simvastatin) Vytorin contains a combination ezetimibe and simvastatin. Ezetimibe reduces the amount of cholesterol absorbed by the body. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or “statins Vytorin reduces levels of “bad” cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of “good” cholesterol (high-density lipoprotein, or HDL). Vytorin is used to treat high cholesterol in adults and children who are at least 10 years old. Vytorin Lipid-lowering agent. Selectively inhibits the absorption of cholesterol (including fitoholesterina) in the intestine (brush border fringes of the small intestine). The mechanism of action different from that of other classes of lipid-lowering drugs (including statins, bile acid sequestrants, fibrates). In contrast, bile acid sequestrants ezetimibe does not increase the excretion of bile acids, in contrast to the statins did not inhibit the synthesis of cholesterol in the liver. When entering the small intestine slows the absorption of cholesterol that leads to a decrease in revenues from its gut to the liver. After 2 weeks reduces the absorption of cholesterol in the intestine by 54% compared with placebo. Uses Vytorin: The primary hypercholesterolemia (heterozygous familial and non-family) as a monotherapy (as an adjunct to diet), in combination therapy with a statin, as an adjunct to diet (in ineffectiveness of statin monotherapy). Homozygous familial hypercholesterolemia: in combination with statins as an adjunct to diet (patients may also receive additional treatment, including LDL apheresis). Homozygous sitosterolemiya: adjuvant therapy to diet. Contraindications Vytorin: Hypersensitivity, acute liver disease or persistent increase in activity of “liver” enzymes, moderate (7-9 points on the scale of Child-Pyuga) and heavy (more than 9 points on the scale of Child-Pyuga) the degree of liver failure. Pregnancy and lactation, age 18 years (effectiveness and safety have not been established). Simultaneous with the appointment of fibrates (at present the efficacy and safety have not been established). Side effects Vytorin: The most frequent (1-10%) monotherapy: headache, abdominal pain, diarrhea. Combination therapy with a statin: headache, fatigue, abdominal pain, constipation, diarrhea, bloating, nausea, myalgia. More than 0.1-1%: allergic reactions, including angioedema and skin rash. In monotherapy the frequency of clinically significant increase in activity of “liver” enzymes (ALT and / or ACT) in three or more times was the same for the drug (0.5%) and placebo (0.3%). In the combined treatment with statins in clinically important increase in activity of “liver” enzymes is 1.3% for patients taking ezetimibe with a statin, and 0.4% for taking only a statin. Increased activity of “liver” enzymes are usually asymptomatic, not accompanied by the formation of stones in the gallbladder and passes as the continuation of treatment and after discontinuation. Clinically significant increase in creatine kinase more than 10 times was comparable in patients receiving the drug as monotherapy or in combinati ----------------------------------------------- 产地国家：英国 原产地英文商品名: Vytorin 10/10MG/Tablets 30Tablets/box  原产地英文药品名: ezetimibe and simvastatin 中文参考商品译名: Vytorin 10/10毫克/片 30片/盒 中文参考药品译名: 依泽替米贝辛伐他汀 生产厂家中文参考译名: 默克公司 生产厂家英文名: MERCK & CO.INC ----------------------------------------------- 产地国家：英国 原产地英文商品名: Vytorin 10/20MG/Tablets 30Tablets/box  原产地英文药品名: ezetimibe and simvastatin 中文参考商品译名: Vytorin 10/20毫克/片 30片/盒 中文参考药品译名: 依泽替米贝辛伐他汀 生产厂家中文参考译名: 默克公司 生产厂家英文名: MERCK & CO.INC ----------------------------------------------- 产地国家：英国 原产地英文商品名: Vytorin 10/40MG/Tablets 30Tablets/box  原产地英文药品名: ezetimibe and simvastatin 中文参考商品译名: Vytorin 10/40毫克/片 30片/盒 中文参考药品译名: 依泽替米贝辛伐他汀 生产厂家中文参考译名: 默克公司 生产厂家英文名: MERCK & CO.INC ----------------------------------------------- 产地国家：英国 原产地英文商品名: Vytorin 10/80MG/Tablets 30Tablets/box  原产地英文药品名: ezetimibe and simvastatin 中文参考商品译名: Vytorin 10/80毫克/片 30片/盒 中文参考药品译名: 依泽替米贝辛伐他汀 生产厂家中文参考译名: 默克公司 生产厂家英文名: MERCK & CO.INC ----------------------------------------------- 产地国家：新西兰 原产地英文商品名: Vytorin 10/10MG/Tablets 30Tablets/box  原产地英文药品名: ezetimibe and simvastatin 中文参考商品译名: Vytorin 10/10毫克/片 30片/盒 中文参考药品译名: 依泽替米贝辛伐他汀 生产厂家中文参考译名: 默克公司 生产厂家英文名: MERCK & CO.INC ----------------------------------------------- 产地国家：新西兰 原产地英文商品名: Vytorin 10/20MG/Tablets 30Tablets/box  原产地英文药品名: ezetimibe and simvastatin 中文参考商品译名: Vytorin 10/20毫克/片 30片/盒 中文参考药品译名: 依泽替米贝辛伐他汀 生产厂家中文参考译名: 默克公司 生产厂家英文名: MERCK & CO.INC ----------------------------------------------- 产地国家：新西兰 原产地英文商品名: Vytorin 10/40MG/Tablets 30Tablets/box  原产地英文药品名: ezetimibe and simvastatin 中文参考商品译名: Vytorin 10/40毫克/片 30片/盒 中文参考药品译名: 依泽替米贝辛伐他汀 生产厂家中文参考译名: 默克公司 生产厂家英文名: MERCK & CO.INC ----------------------------------------------- 产地国家：新西兰 原产地英文商品名: Vytorin 10/80MG/Tablets 30Tablets/box  原产地英文药品名: ezetimibe and simvastatin 中文参考商品译名: Vytorin 10/80毫克/片 30片/盒 中文参考药品译名: 依泽替米贝辛伐他汀 生产厂家中文参考译名: 默克公司 生产厂家英文名: MERCK & CO.INC