英文药名：OXINORM Powder(Oxycodone Hydrochloride Hydrate)

中文药名：盐酸羟考酮散剤

生产厂家：盐野义制药
治疗类别名称
癌症疼痛治疗用散剤
欧文商標名
OXINORM
一般的名称：
オキシコドン塩酸塩水和物（JAN）［日局］
Oxycodone Hydrochloride Hydrate
化学名：
(5R)-4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one monohydrochloride trihydrate
分子式：
C18H21NO4・HCl・3H2O
分子量：
405.87
化学構造式：

性状：
它是一种白色结晶粉末。
水，并在甲醇或乙酸（100），乙醇（95）易溶于难溶到稍溶于乙酸酐，并在二几乎不溶于乙醚。
它通过光变。
适应症
各种癌症中的镇痛的中度至重度疼痛
用法用量
成人每天口服给药：分4次服，每日口服10-80毫克。该剂量可以适当地根据症状进行调整。
包装规格
散剤
2.5mg： 30包/盒（0.5克×30包）

5mg：    30包/盒（1克×30包）

10mg： 30包/盒（1克×30包）

20mg： 30包/盒（1克×30包
生产厂商
盐野义制药有限公司
完整处方资料附件：http://www.info.pmda.go.jp/go/pack/8119002B2023_1_06/
OXINORM Powder（Oxycodone hydrochloride hydrate）
OXINORM Powder 2.5mg（オキノーム散2.5mg） 
Brand name : OXINORM Powder 2.5mg
　Active ingredient: Oxycodone hydrochloride hydrate
　Dosage form: white powder
　Print on wrapping: (Face) オキノーム散2.5mg 2.5mg/包(0.5g)0.5%, (Back) OXINORM
OXINORM Powder 5mg（オキノーム散5mg） 
Brand name : OXINORM Powder 5mg
　Active ingredient: Oxycodone hydrochloride hydrate
　Dosage form: white powder
　Print on wrapping: (Face) オキノーム散5mg 5mg/包(1g)0.5%, (Back) OXINORM
OXINORM Powder 10mg（オキノーム散10mg）
Brand name : OXINORM Powder 10mg
　Active ingredient: Oxycodone hydrochloride hydrate
　Dosage form: white powder
　Print on wrapping: (Face) オキノーム散10mg 10mg/包(1g)1%, (Back) OXINORM
OXINORM Powder 20mg（オキノーム散20mg）
Brand name : OXINORM Powder 20mg
　Active ingredient: Oxycodone hydrochloride hydrate
　Dosage form: white powder
　Print on wrapping: (Face) オキノーム散20mg 20mg/包(1g)2%, (Back) OXINORM
Effects of this medicine
This medicine acts on opioid receptors in the central nervous system, thereby relieving pain.
It is usually used as an analgesic for various types of cancer accompanied with moderate to severe pain.
Before using this medicine, be sure to tell your doctor and pharmacist
If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have respiratory function disorder, bronchial asthma, heart failure, a history of convulsions, paralytic ileus, acute alcoholic poisoning, hemorrhagic colitis or bacterial diarrhea.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
In general, for adults, take 0.125 to 1 g [2.5 to 20 mg as oxycodone hydrochloride (anhydride)] at a time, 4 times a day (every 6 hours). The dosage may be adjusted according to your symptoms. In the beginning, take 0.125 to 0.25 g (2.5 to 5 mg) at a time, 4 times a day (every 6 hours). If you have been treated with any other analgesic agents, the dosage of this medicine is properly decided with attention to adverse reactions in consideration of the dosage of other agents and the analgesic duration. Furthermore, the dosage is adjusted to provide the appropriate analgesic effect and to minimize the adverse reactions. This product contains 20 mg of oxycodone hydrochloride (anhydride) per sachet. Strictly follow the instructions.
You may also take this medicine, if your pain suddenly becomes severe during the treatment with other analgesic agents.
If you still have a pain or feel very sleepy, consult with your doctor.
If you miss a dose, take it as soon as you remember and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so. Sudden discontinuation of taking this medicine may cause adverse events.
Precautions while taking this medicine
Since this medicine may cause drowsiness or dizziness, avoid driving a car or operating dangerous machinery.
Alcohol may enhance the effects or the adverse reactions of this medicine.
If you are breastfeeding, avoid breastfeeding while taking this medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include constipation, nausea, vomiting, drowsiness, somnolence, dizziness, rash and hives. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
facial pallor, breathlessness, swelling around eyes and/or mouth (lips)  [shock, anaphylaxis]
desire for the medicine even when taking the medicine is not needed  [dependence]
breathlessness, shortness of breath  [depressed respiration]
disoriented, speaking in tongues, feeling as if the thing which is not in fact were visible or audible  [confusion, delirium]
constipation, feeling of fullness in abdomen, severe pain in abdomen  [paralytic ileus, toxic megacolon]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
Keep the medicine out of the reach of infants and children. Store it at room temperature (1 to 30 degrees Celsius) away from light and moisture.
Do not give the medicine to anyone else.
Return the remainder or the medicine which is no longer needed to your hospital or pharmacist.
Shionogi & Co., Ltd. Internal
Revised: 7/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.